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Biomedical subjects

J Lindner

Publications and source records attributed to J Lindner.

At least 127 records · Page 7Linked to original sources
PubMed1978

[Contribution to wet and dry weights of mesenchymal and parenchymatous organs of humans and rats during the course of life (author's transl)].

The wet and dry weights of parenchymatous (lung, heart, liver, kidney) and of mesenchymal organs (aorta, skin, xiphoid cartilage) of humans and rats (both sexes) were investigated during the course of life. Furthermore, these investigations were done on the following rat organs: brain (divided in cerebrum as well as in cerebellum plus pons), spleen, rib cartilage, testis and ovar. The water content of these tissues and organs of both species was calculated by means of their wet and dry weights. The dry weights of the investigated parenchymal and mesenchymal organs of both species remain constant during the whole course of life (pastly until the high senile age)--using freeze-drying. The same is true for the water content: constancy without significant decrease during the investigated life periods and without sex dependent differences.

Aging↗
PubMed1978

[Age-dependent DNA-content of brain, testis and ovar in men and rats (author's transl)].

The DNA-content of brain, testis and ovar of Wistar rats (inbred strain) was quantitatively analysed. We observed no significant differences between the several parts of the cerebrum, but between the cerebrum and the cerebellum. Furthermore we demonstrated alterations (with increase and decrease) of the DNA content of all brain parts as well as of testis and ovar during the course of life of this Wistar rat strain. These results and further investigations of the water content as well as of the absolute and of the relative weight of brains of these rats (in comparison to humans) extend the data and our knowledge about these subjects. It is possible to differentiate growth phases (by means of the DNA assays, which correlate with the morphologically well defined growth phases. Finally these results are fundamentals and presuppositions for investigations of the production metabolism of these organs because the DNA content is a better parameter (reference or relation figure, resp.) than the dry or wet weights and the protein or the nitrogen contents.

Adult↗
PubMed1978

[New results on ageing of connective tissue (author's transl)].

Some new results on ageing of connective tissue are demonstrated, regarding not only mesenchymal, but also parenchymal organs of human and rat (both sexes). These results show that ageing of connective tissue is more a dynamic process (with measurable metabolic parameters of the several connective tissue cells and their products) than a passive or so-called degenerative connective tissue process. The bradytrophy concept of connective tissue cannot be accepted any longer. Then connective tissue cells can produce metabolic rates of the same level like parenchymal cells. The different organs possess partly common basic processes partly differences in connective tissue ageing, dependent on the composition and patterns of proteoglycans resp. of GAG and collagen types, furthermore dependent on localisation, structure and function. The results on ageing of connective tissue are useful for better understanding of ageing processes of parenchymal organs. Then their ageing is influenced essentially by the ageing of the own connective tissues. The turnover, more than the number of mesenchymal and parenchymal cells, decreases with ageing. More old than young cells seem to exist in old tissues and organs. The performance of ageing connective tissue cells can be constant or increase or decrease. Many mesenchymal and parenchymal organs develop a so-called "ageing-fibrosis".

Aged↗
PubMed1978

[Functional treatment of fractures of the calcaneum (author's transl)].

62 fractures of the calcaneum treated by functional therapy have been reviewed. Good results were observed in 63 per cent of the cases, whereas 37 per cent showed satisfactory results. Fractures of the Typ A and B and those of Typ C without other injuries demonstrated good results. Therefore functional therapy can be recommended. Although Typ C fractures combined with other injuries have poor end-results, operative therapy should be delayed because of the over-all risk of the patient. A trial of functional therapy should be initially instituted.

Calcaneus↗
PubMed1977

Bone healing.

Secondary fracture healing with callus fomation involves the immediate reaction of this special kind of connective tissue (as well as others) with rapid increase in the reduplication of periosteal, paraosseal, and, to a lesser extent, endosteal cells. There is increased metabolism of glycosaminoglycan collagen synthesis, and transformation of fibrous and cartilaginous callus, combined with mineralization of the latter and intensified vascular invasion into bone. The glycosaminoglycan content decreases with progressing ossification, while the collagen content increases. In the beginning stages of whole bone fracture healing, vascularization is the first step responsible in part for the several maxima of synthesis and total contents of the specific cell products. Extension of ossification and remodeling in the final phases of bone fracture healing depend on other local and general factors, as well as biophysical and biological factors.

Animals↗