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Biomedical subjects

J Lindenmann

Publications and source records attributed to J Lindenmann.

At least 73 records · Page 4Linked to original sources
PubMed1972

Cellular receptors: binding of radioactively labeled anti-alloantiserum.

RAT ALLOANTISERA OF THE FOLLOWING SPECIFICITIES WERE OBTAINED AFTER SINGLE SKIN GRAFT REJECTION: DA anti-BN, BN anti-DA, DA anti-Lewis, and Lewis anti-DA. Anti-alloantibodies were raised by injecting the first two alloantisera into (DA x BN)F(1) hosts and the last two alloantisera into (DA x Lewis)F(1) hosts. In this manner, four anti-alloantisera were raised: anti-(DA anti-BN), anti-(BN anti-DA), anti-(DA anti-Lewis), and anti-(Lewis anti-DA). From each anti-alloantiserum a gamma globulin fraction was prepared and trace labeled with (125)I. The labeled anti-alloantibodies could be shown to be fixed preferentially by red cells coated with the alloantibody used to induce them. They were also preferentially fixed by normal rat lymphoid cells presumed to carry recognition structures similar to alloantibody. For instance, anti-(DA anti-BN) was fixed by BN red cells coated with DA anti-BN and by normal DA lymphoid cells presumed to carry RS(BN). Conversely, anti-(BN anti-DA) was fixed by DA red cells coated with BN anti-DA and by normal BN lymphoid cells, carrying RS(DA). Absorption and inhibition experiments showed that alloantibodies and normal lymphoid cells compete for the same labeled anti-alloantibodies. We conclude that cellular receptors and circulating alloantibody are antigenically similar: They have the same aliotype.

Animals↗
PubMed1972

Immunogenicity of egg-grown influenza vaccine: inhibition by immunization of recipients with host antigen.

Rabbit antibody directed against normal allantoic fluid reduced the protective power of influenza vaccine prepared from egg-grown PR8 virus. A similar vaccine prepared from mouse lung virus was not inhibited. Preimmunization of mice with normal allantoic fluid or with egg-grown influenza B/Lee vaccine (crude or purified) inhibited the protective power of PR8 egg vaccine but did not affect a similar lung vaccine.

Animals↗
PubMed1971

Cellular receptors. effect of anti-alloantiserum on the recognition of transplantation antigens.

The possibility that a rat alloantiserum DA anti-Lewis possesses similar recognition structures for Lewis transplantation antigens, as do DA immunocompetent cells, was investigated by raising an antiserum against this alloantiserum in (Lewis x DA)F(1) hosts. This antiserum, as well as one provoked by injecting DA lymphoid cells, was active against recognition structures for Lewis antigens of DA immunocompetent cells. The anti-(DA anti-Lewis) antiserum displayed the same degree of specificity as was found previously for anti-recognition structure sera prepared by injecting parental strain lymphoid cells into F(1) hosts. Since the activities of antisera raised against cell-bound receptors or against the antigen-binding region of an immunoglobulin were indistinguishable, it was concluded that the functional part of cell-associated receptors might be structurally similar to the variable portion of an immunoglobulin.

Animals↗