Search PubMed⌕ Search

Biomedical subjects

J Lindberg

Publications and source records attributed to J Lindberg.

At least 91 records · Page 5Linked to original sources
PubMed1983

Autoantibodies to Tamm-Horsfall protein in acute and chronic hepatitis.

The levels of antibodies of the IgG, IgA and IgM class against the Tamm-Horsfall glycoprotein (anti-THP) were determined in 108 patients with the following diagnoses: acute hepatitis A, acute hepatitis B, acute hepatitis non-A non-B, chronic hepatitis B, chronic hepatitis non-A non-B and chronic autoimmune hepatitis. The mean levels of antibodies of the IgM class were higher in all types of hepatitis than in healthy controls, while the mean levels of anti-THP of the IgA and IgG class were increased in acute hepatitis B only. 13 of 20 patients (65%) with acute hepatitis B exhibited increased levels of anti-THP of the IgA class compared to 6-18% of the patients in the other categories. The increased levels of anti-THP of the IgA class could not be attributed to elevated serum IgA but instead were correlated with the levels of serum aminotransferase. The possible impact of this particular association of anti-THP with acute hepatitis B is discussed.

Acute Disease↗
PubMed1982

Clearance of hepatitis B e-antigen in chronic hepatitis B infection.

HBeAg and anti-HBe were determined by radioimmunoassay (Abbott HBe) in serial serum samples from 22 patients who had been HBsAg-positive for more than 1 year. Seventeen patients (77%) were HBeAg-positive at onset of illness. Eight of these patients were persistently HBeAg-positive during 2.5-8.5 years' follow-up study (mean, 5.4 years). Chronic persistent hepatitis (CPH) developed in one of these patients and chronic active hepatitis (CAH) in seven patients. Nine persistently HBsAg-positive patients were transiently HBeAg-positive. Seven of these patients developed CPH, and they all lost HBeAg within 2 years of onset of illness. One patient, who was HBeAg-positive for 4 years, developed CAH with cirrhosis after loss of HBeAg. In five patients, HBeAg could not be detected. They were anti-HBe-positive at onset of illness; four developed CAH and/or cirrhosis, and one developed CPH. Progression from CPH or nonspecific reactive hepatitis to CAH was observed in two persistently HBeAg-positive patients. Prolonged detection of HBeAg in CPH is a reason for repeated liver biopsy to reevaluate the diagnosis. The behaviour of the e-antigen system in CAH seems to be more complex than in CPH, perhaps indicating a different pathogenetic mechanism of chronicity in CAH.

Adult↗
PubMed1982

Gluten-free diet in chronic active hepatitis associated with intestinal villous atrophy.

Three patients out of 16 with chronic active hepatitis exhibited villous atrophy in biopsy specimens from the upper jejunum. These patients were put on a gluten-free diet for one year, and the intestinal changes normalized in two of the patients, but did not heal in the third patient. The levels of alanine aminotransferase and IgG, did not decrease under the gluten-free diet. The liver disease of the patients with intestinal changes ran a serious course: one patient died in hepatic coma, and one patient developed portal hypertension with recurring hematemesis. These complications did not appear in the patients with healthy intestine. It is suggested that the three patients suffered from both chronic active hepatitis and coeliac disease, which appeared concomitantly on the basis of a genetic disposition for both diseases.

Adolescent↗
PubMed1979

Progression of hepatitis non-A, non-B to chronic active hepatitis: a histological follow-up of two cases.

Two patients with histologically verified acute hepatitis but without any serological evidence of hepatitis A or hepatitis B infection are described. In both cases the acute attack of hepatitis type 'non-A, non-B' progressed histologically and clinically to chronic active hepatitis within a two-year period. One of the patients died from liver insufficiency a year later, while the other is still alive after eight years of follow-up. The two cases illustrate that a progression of acute hepatitis 'non-A, non-B' to chronic liver disease may occur just as has been reported for hepatitis B infection.

Acute Disease↗
PubMed1979

Humoral immunoreactivity in chronic active hepatitis: relation to HLA antigens.

43 patients with chronic active hepatitis (CAH) exhibited significantly higher levels of antibodies against measles and polio type 2 und 3 when compared to 43 age- and sex-matched healthy controls. No significant differences were found for antibodies against polio type 1, rubella, herpes simplex, mumps virus, and tetanus. There was no correlation between antibody levels and the presence of HLA-B8 and/or HLA-B12. The antibody response to vaccination with polio vaccine (killed) and tetanus toxoid was not higher in CAH patients carrying HLA-B8 and/or HLA-B12 than in patients without these antigens. The results indicate that CAH is associated with an increased immunoreactivity, which is, however, not linked to HLA-B8 and/or HLA-B12.

Adolescent↗
PubMed1979

Nitrofurantoin-induced chronic liver disease. Clinical course and outcome of five cases.

Adverse liver reactions associated with nitrofurantoin treatment are rare but important complications. Both acute and chronic liver damage have been described. The present report describes five patients who developed chronic liver disease after 1 to 3 years of continued nitrofurantoin treatment. Liver histology was consistent with chronic active hepatitis in four patients, while postnecrotic cirrhosis was observed in one case. Follow-up examinations 2 to 3 years after withdrawal of the drug showed marked improvement clinically and in most cases also histologically.

Chemical and Drug Induced Liver Injury↗
PubMed1979

Intestinal villous atrophy in chronic active hepatitis.

Three out of 16 patients with chronic active hepatitis (CAH) had total or subtotal villous atrophy in a suction biopsy taken from the upper jejunum. One of the three patients had a history of intestinal dysfunction. The patients with abnormal intestinal mucosa had lower levels of serum albumin and higher levels of IgG than patients without intestinal mucosal changes. The occurrence of intestinal villous atrophy in CAH may be due to a genetically determined disposition to CAH and coeliac disease associated with HLA-B8, which was carried by all three patients. The present findings have led to trials with gluten-free diet in CAH associated with intestinal villous atrophy.

Adolescent↗
PubMed1978

Outcome of chronic active hepatitis: influence of histocompatibility antigens and triggering factors.

Twenty-five patients with chronic active hepatitis triggered by external factors (viruses or drugs) and 20 patients with cryptogenic chronic active hepatitis were studied for two to five years. The first group showed a significantly higher frequency of clinical and biochemical resolution at the end of the observation period than did the second group. The group with cryptogenic disease had a predominance of females carrying the histocompatibility antigen HLA-B8, whereas the group with virus- or drug-induced hepatitis did not differ from normal controls in regard to the distribution of HLA antigens. HLA-B8 and HLA-B12 were found in all but two patients in the group with cryptogenic hepatitis; this group of patients had elevated levels of gamma-globulin and autoantibodies in their sera more frequently than did the group with virus- or drug-induced disease. The results suggest that there are at least two types of chronic active hepatitis: one genetically determined, with signs of enhanced immunoreactivity and with a low degree of healing in five years; and another type triggered by external factors and without predisposing genetic factors. The data suggest that the clinical outcome is more favorable for patients with the second type of chronic active hepatitis.

Chemical and Drug Induced Liver Injury↗
PubMed1978

Serologic markers of hepatitis A and B in chronic active hepatitis.

Sera from 44 patients with a well-documented diagnosis of chronic active hepatitis (CAH) were analysed for antibodies to hepatitis A virus (anti-HAV), hepatitis B surface antigen (HBsAg) and anti-HBs, e-antigen (HBeAg) and anti-HBe, as well as antibodies to hepatitis B core antigen (anti-HBc). Twenty-two patients had serologic evidence of hepatitis A infection. The frequency of anti-HAV was low in patients under 50 years of age (21%) but high among older patients (72%). There was, however, no significant difference between patients and age-matched controls regarding the prevalence of anti-HAV in serum. Markers for hepatitis B virus were found in 10 patients or 23% as compared with about 10% in Swedish blood donors. The results indicate that hepatitis A virus is of little importance in the pathogenesis of CAH and confirm the association between hepatitis B virus and development of chronic active hepatitis.

Adolescent↗
PubMed1977

Genetic factors in the development of chronic active hepatitis.

In 14 of 16 patients with chronic active hepatitis (C.A.H.) who did not have HLA antigens B8 and/or B12 an external triggering factor (drug or virus) could be demonstrated at onset of symptoms. In contrast external factors were involved in only 11 of 25 cases of C.A.H. in patients with HLA-B8 and/or B12. In the latter group antinuclear antibodies were less common in cases possible triggered by external agents compared with cases in which no such factor was demonstrated. The results suggest that there are at least two pathogenetically different types of C.A.H.---one genetically determined type in which no external factor is involved and in which autoimmune phenomena are common, and another type triggered by environmental agents and not involving predisposing genetic factors.

Autoantibodies↗
PubMed1977

Coenzyme-B12 therapy in acute viral hepatitis.

Extra vitamins are needed to repair tissue damage and compensate for diminished hepatic storage during viral hepatitis. Coenzyme-B12 has recently been synthesized and ought to have a favourable effect on the damaged liver cell as has previously been reported for cyanocobalamin, since it is better absorbed by oral administration and to a greater extent accumulated in the liver. Two groups of patients from the same hepatitis A epidemic were treated with either coenzyme-B12 or cyanocobalamin. A more rapid return of serum aminotransferase (S-ALAT) levels to normal was observed in the group treated with coenzyme-B12.

Acute Disease↗
PubMed1977

Long-term outcome of Hemophilus influenzae meningitis related to antiobiotic treatment.

Of 82 patients treated for Hemophilus influenzae meningitis from 1968 to 1975, a total of 22 (26.8%) showed neurologic or psychologic sequelae, or both. Auditory impairment was the most common type of sequelae; it occurred in 15 patients. Complications during acute illness were more frequent in patients who later developed sequelae than in patients who recovered completely. Sequelae were more often found in patients who received both ampicillin and chloramphenicol concomitantly compared with patients who were treated with one of these drugs. A possible antagonistic interaction between ampicillin and chloramphenicol is discussed.

Ampicillin↗
PubMed1975

Trigger factors and HL-A antigens in chronic active hepatitis.

Forty-six patients with histologically verified chronic active hepatitis (CAH) were divided into three groups according to whether the CAH was virus-induced, drug-induced, or cryptogenic. The frequency of the HL-A antigens 1 and 8 was increased in the cryptogenic group while the other groups did not differ significantly from healthy controls. Autoantibodies were often found in high titres in the drug-induced and cryptogenic groups but were infrequent in the virus-induced group.

Adolescent↗