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Biomedical subjects

J Linares

Publications and source records attributed to J Linares.

At least 37 records · Page 2Linked to original sources
PubMed1985

beta-thromboglobulin (beta-TG) and platelet factor 4 (PF4) in obstetrical cases.

The plasma levels of beta-Thromboglobulin (beta-TG) and Platelet Factor 4 (PF4) were measured in patients during the normal obstetrical period and in pre-eclampsia. A significant increase was observed in the two proteins with respect to the non-pregnant control group but no difference was seen between pregnancy and puerperium in either the normal or pre-eclamptic cases. The one significant variation in the concentration of the two proteins was a sharp rise during parturition. There was no correlation between beta-TG, PF4 and either the platelet count or creatinine but urea and uric acid did show a slight correlation with the two platelet proteins.

Adult↗
PubMed1985

[Comb-like rhythm: an EEG pattern peculiar to leucinosis].

EEG and clinical aspects of a newborn baby with maple syrup urine disease are presented. EEG shows in central areas "Comb-like rhytms" with pseudo-periodic background activity. These patterns seem peculiar to maple syrup urine disease according to Trottier et al. (1975). EEG findings may suggest screening for aminoacids.

Electroencephalography↗
PubMed1984

Factor VIIIR:Ag/Factor VIII:C and their ratio in obstetrical cases.

Factor VIIIR:Ag and Factor VIII:C levels were found to be significantly increased during pregnancy, labor and puerperium, but not to the extent observed by European and American authors. The ratio Factor VIIIR:Ag/Factor VIII:C was elevated only between the third and sixth hour of labor with respect to early labor, and during parturition and early puerperium with respect to late labor. However, this ratio was in the same range as the normal non-pregnant controls, but in the cases of complicated pregnancy, the ratio reached values much higher than the normal. It was concluded that determination of the ratio appears to be of little value in normal cases but may be of use when there are obstetrical complications. Studies are being performed to try to explain the limited rise in Factor VIII:Ag and Factor VIII:C levels observed in our cases.

Antigens↗
PubMed1984

Destruction of IgG anti-A sensitized erythrocytes by mononuclear leucocytes from normal and ABO haemolytic disease affected infants.

Studies were undertaken to investigate the antibody-dependent cell-mediated cytotoxicity (ADCC) activity of mononuclear leucocytes (MNL) from cord and healthy adult blood and that from infants with ABO haemolytic disease. The ADCC levels of MNL from both types of newborn blood were found to be higher than that of MNL from adult blood. The extent of ADCC was positively related to the degree of antibody sensitization of the red cells and to the effector cell target cell ratio. The ADCC activity was effected mainly by the adherent cell fraction and could be inhibited by cytochalasin B, hydrocortisone and also by high concentrations (more than 0.5 mg/ml) of non-specific free human IgG. Phagocytosis was also demonstrated to be an important mechanism in the destruction of IgG anti-A coated red cells by the MNL.

ABO Blood-Group System↗
PubMed1983

Studies on the binding of IgG and F(ab) anti-A to adult and newborn group A red cells.

The values of the functional affinity constants for the binding of human IgG anti-A and its F(ab) derivative with adult and newborn group-A red cells have been determined. The values obtained for both monovalent and bivalent antibody with both types of cells were of the same order (about 1 X 10(8) M-1), indicating that IgG anti-A binds to red cells only by one of its F(ab) arms.

ABO Blood-Group System↗
PubMed1982

Plasma fibrinogen concentration in ABO-hemolytic disease of the newborn.

Plasma fibrinogen and total serum proteins were measured in infants affected by ABO-hemolytic disease and in normal infants' cord blood and blood taken 48 h after birth. The average plasma fibrinogen concentrations in the blood of infants with ABO-hemolytic disease was 447.36 mg/dl as compared with 267.09 mg/dl (p less than 0.005) in cord blood and 313.82 mg/dl (p less than 0.005) in blood samples taken 48 h after birth. A simple 'autoagglutination' test is found to be helpful when establishing the diagnosis of ABO-hemolytic disease.

ABO Blood-Group System↗