Search PubMed⌕ Search

Biomedical subjects

J Lien

Publications and source records attributed to J Lien.

31 records · Page 2Linked to original sources
PubMed1978

Changes in red cell space of bone in hypocalcemic states: studies in rat femur.

With the use of technetium-99m-labeled red cells, the red cell space of the femur was found to be increased in rats fed a 0.01 percent Ca diet for 4 wk, at which time they were also hypocalcemic. Rats fed the same diet for 2 wk did not demonstrate hypocalcemia nor hypervascularity of the femur. Thyroparathyroidectomized (TPTX) rats fed the calcium-deficient diet produced hypocalcemia nor hypervascularity as did TPTX rats fed a normal diet for 4 wk. However, bone vascularity was normal at 2 wk post-TPTX (normal diet) when the degree of hypocalcemia was less marked. Inhibition of prostaglandin synthetase with oral indomethacin 0.2 mg/100 g per 12 h for 60 h did not alter the red cell space estimates but did increase bone blood flow in both normal and calcium-deficient animals. Acute restoration of normocalcemia with CaCl2 orally in the calcium-deficient rats did not revert the bone hypervascularity. The evidence suggests that in these models of hypocalcemic states, the rise in the vascular space of bone does not result from the influence of PTH, calcitonin, diet, or prostaglandins.

Animals↗
PubMed1977

Changes in red cell, plasma, inulin, and total water compartments in rat femurs. Comparison of vitamin D deficiency and diphosphonate induced rickets.

The vascular space, as measured with the use of 99m-technetium-labelled red cells and 131I-serum albumin, as well as the 14C-inulin and 3H2O fluid compartments were measured in rats which had been made rachitic by the use of a low phosphate vitamin D-deficient diet. A similar group of rachitic animals fed vitamin D2 50 IU, 5 and 3 days prior to sacrifice and a weight-matched control group were also studied. The same spaces were measured in rats made rachitic by daily s.c. injections of ethane-1-hydroxy-1,1-diphosphonate (EHDP) for 4 weeks and a weight-matched saline injected control group. Findings indicated that the red cell and RISA spaces were unchanged in the untreated D-deficient group as compared to controls but increased after being repleted with vitamin D. By contrast, the vascular space was depressed in the EHDP-treated group. The water content was elevated in D-deficient rickets returning towards normal on healing, whilst both inulin and water spaces were increased in the EHDP-treated animals. Thus, while the extravascular space reflected the presence of osteoid, the vascular space depended on cellular turnover and the process of mineralization.

Animals↗
PubMedDate not supplied

A successful laboratory outreach program.

Many economists say the recession is ending--if not over already. Those of us in health care are still facing trying times, and health-care reform may be just around the corner. Many hospitals are developing or enhancing laboratory outreach programs to ease their financial burdens. In the first of a two-part "As We See It," CLMR spoke with expert laboratorians who discuss the need for an outreach program and who should be involved in its development, as well as how hospital laboratories can establish the proper business culture to run a successful program. We asked: How do you develop and operate a successful laboratory outreach program?

Laboratories, Hospital↗
PubMedDate not supplied

Integrated regional laboratory systems: implications for staffing and skill mix requirements.

Significant changes are occurring in the organization and delivery of clinical laboratory services. Many laboratorians are concerned that these changes will adversely affect the quality of these services as well as their own careers. The purpose of this paper is to review the changes occurring in health care and to discuss their impact on laboratory and other health-care services. It will present the concept of the postmodern laboratory and the skills and skill mix of personnel needed by the new organizational paradigm.

Clinical Competence↗
PubMedDate not supplied

New path for health-care leadership: clinical systems management. CLMA Clinical Systems Management Task Force.

This article sets forth a concept and an action plan to support the educational needs for the clinical systems manager. This article describes the roles, competencies, and tasks of the clinical systems manager and defines specific intermediate and long-term steps. Clinical systems management is umbrella terminology used to describe an array of related jobs including, but not necessarily limited to, multidepartmental or interdisciplinary management, regional or health system-wide laboratory management, and traditional laboratory management. In general, clinical systems management recognizes the emergence of new jobs, with the primary responsibility of leading the integration of clinical services within health-care systems.

Data Collection↗
PubMedDate not supplied

The clinical services manager: a curriculum for the 21st century.

The dynamism of change in the evolution of integrated health-care systems is driving change in the skills and competencies required to manage diagnostic services. Formal educational preparation and practical experience in a wider array of disciplines will be essential to the backgrounds of those who will be chosen for these new and ever more complex roles. Curricular elements relevant to this educational challenge are outlined herein. This article is intended to expand on the position of CLMA as reflected in the position paper "New Path for Health-Care Leadership: Clinical Systems Management," issued in August 1997 (1).

Clinical Laboratory Information Systems↗