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Biomedical subjects

J Lieb

Publications and source records attributed to J Lieb.

At least 37 records · Page 2Linked to original sources
PubMed1983

Elevated levels of prostaglandin E2 and thromboxane B2 in depression.

Plasma prostaglandin E2 (PGE2) and thromboxane B2 (TXB2) levels were measured in 30 depressed outpatients. Plasma PGE2 was increased in all but one of these patients (p less than 0.001) and all had increased levels of TXB2 (p less than 0.001). Since monamine oxidase inhibitors inhibit brain prostaglandin synthesis, and tricyclic antidepressants may antagonize prostaglandin actions, these observations suggest new approaches to depression research.

Affect↗
PubMed1980

Linoleic acid in the treatment of lithium toxicity and familial tremor.

Lithium inhibits the synthesis of prostaglandin (PG) EI by blocking the mobilisation of dihomogammalinolenic acid (DGLA). Toxicity due to lithium might re related to reduced PGEI formation. In five patients who developed toxic effects on low doses of lithium, linoleic acid in the forms of the safflower oil was given in an attempt to raise levels of the linoleic acid metabolite, DGLA. In al five patients the safflower oil was effective in remitting the symptoms of neurotoxicity. Safflower oil was also effective in a patient with familial tremor.

Adult↗
PubMed1980

Lithium treatment of hypothermia caused by electric shock.

Prostaglandins have hyperthermic as well as hypothermic effects, and lithium, which inhibits the conversion of dihomogammalinolenic acid to PGE1, can produce hyperthermia. Electroconvulsive shock raises prostaglandin F in rat cerebral cortex and in the case presented here lithium normalized temperature in a patient who became hypothermic after she accidentally received an electric shock.

Adult↗
PubMed1978

Brief communication treatment of delusional depression with tranylcypromine.

Patients with depressions accompanied by delusional thinking are reported to respond poorly to tricyclic antidepressants. We present four cases of delusional depression successfully treated with tranylcypromine. Three patients had previously been treated unsuccessfully with adequate trials of tricyclic antidepressants and one had been treated with a tricyclic-phenothiazine combination with a poor response. These four patients experienced a dramatic reduction in depression and delusional thinking when treated with tranylcypromine. On the basis of these cases, tranylcypromine appears to be an effective treatment for some patients with delusional depressions.

Affective Disorders, Psychotic↗