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J Levitt

Publications and source records attributed to J Levitt.

71 records · Page 4Linked to original sources
PubMedDate not supplied

Preliminary study of frontal lobe 1H MR spectroscopy in childhood-onset schizophrenia.

Cerebral 1H MR spectra were recorded in 13 children and adolescents with schizophrenia and 12 healthy children and adolescents. Stimulated echo acquisition mode (STEAM) sequence was used to localize an 8-ml voxel bilaterally in the frontal gray matter. The frontal gray matter metabolite ratios for NAA/Cr, Ch/Cr, Glx/Cr, and mI/Cr in schizophrenic children and adolescents were 1.08 +/- .28, .64 +/- .23, 1.09 +/- .30, and .60 +/- .24, respectively. In comparison, these ratios were 1.59 +/- .35, .74 +/- .27, 1.23 +/- .36, and .58 +/- .29 in healthy children and adolescents. Decrease in the frontal lobe NAA/Cr of schizophrenic children and adolescents was statistically significant (P < .001). In contrast, the MR spectra localized bilaterally in the occipital gray matter (8 ml) showed no significant changes between the patients and the controls. In the occipital gray matter, the metabolite ratios were 1.21 +/- .26,.52 +/- .08, 1.00 +/- .11, and.55 +/- .12 inpatients versus 1.30 +/- .23, .45 +/- .10, 1.15 +/- .20, and .48 +/- .19 in controls. Our preliminary finding of reduced NAA/Cr ratio in the frontal gray matter is consistent with the neurodevelopmental models emphasizing dysfunction of frontal lobe areas in patients with schizophrenia.

Adolescent↗
PubMedDate not supplied

Impacting quality: assessment of a hospital-based geriatric acute care unit.

This article describes a preliminary evaluation of the effectiveness of an inpatient geriatric acute care service (GACS) unit specifically designed to care for elderly nursing home residents. The study employed a retrospective, matched-control group design. Two separate control groups were used to provide a more thorough picture of the effectiveness of the GACS. Subjects for the study included a GACS "intervention" group consisting of 334 residents from nineteen nursing homes, an acute care "other hospital" control group consisting of 309 residents from the same nursing homes as the intervention group who were treated at other area hospitals, and an acute care "same hospital" control group, consisting of 74 matched nursing home residents who were hospitalized at the same hospital, but in a different unit than the intervention group. The length of the first hospitalization, the total length of stay during the study period, the number of rehospitalizations of the patients, and mortality were examined. Patients treated at the GACS were less likely to die, had shorter lengths of stay, less rehospitalization, and longer times between hospitalizations than both of the control groups. The GACS unit is a successful answer to the complex acute hospital care needs of the elderly nursing home population.

Aged↗