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Biomedical subjects

J Levine

Publications and source records attributed to J Levine.

At least 307 records · Page 17Linked to original sources
PubMed1975

Panel 2: phase II investigations.

At the end of Phase II, a decision must be made as to whether or not the drug should be developed as a therapeutic agent. Such a decision may be based on many criteria in addition to the scientific data derived from the Phase II study. At this point, expert judgment is needed. One should like to assume that if the decision is made to proceed with the increasingly expensive and laborious process of further development, the drug will, barring some completely unforeseen misadventure, ultimately find its way into clinical therapeutics. Phase II studies, therefore, are the most crucial stage in the course of drug development. Planning of these studies requires great care and investigators of the highest caliber should be used for their conduct. The escalating costs of new drug development are resulting in an undesirable imbalance of efforts in the direction of studies characterized more by easily defined end points than by therapeutic needs. Industry, academia, and the FDA must all be concerned with facilitationg studies in areas of most-needed therapeutic advances.

Clinical Trials as Topic↗
PubMed1975

Infrared identification test for scopolamine as the hydrobromide.

The method of preparation of scopolamine hydrobromide affects the infrared (IR) spectrum of the product. A column chromatographic procedure is used to both isolate the drug from tablets and injections and form the hydrobromide salt. This yields reproducible IR spectra and thus constitutes an identity test for scopolamine hydrobromide.

Chromatography↗
PubMed1974

Homology between Burkitt herpes viral DNA and DNA in continuous lymphoblastoid cells from patients with infectious mononucleosis.

At least 90% of the sequences of purified, in vitro labeled, DNA from Epstein-Barr virus (prepared from HR-1, Burkitt's lymphoblastoid cells) are homologous to the DNA of the herpes virus contained in cell lines derived from patients with infectious mononucleosis. The thermal stability of the homologous and heterologous hybrid DNA molecules could not be differentiated, indicating at least 97% matching of base pairs between DNA of Epstein-Barr virus and the herpes viral DNA contained in the lymphoblasts from patients with infectious mononucleosis.

Base Sequence↗