Biomedical subjects

J Lepej

Publications and source records attributed to J Lepej.

31 records · Page 2Linked to original sources

PubMed1989

[Dynamic scintigraphy of the kidneys using a diuretic].

The authors describe the application of the method of dynamic scintigraphy of the kidneys, using a diuretic, in patients with signs of stasis in the upper urinary pathways, based on findings of excretory urography and standard radioisotope examination of the kidneys. They obtained three groups of results: 1. Obstruction during the standard radioisotope examination of the kidneys became normal after administration of the diuretic. 2. The obstruction receded during the standard radioisotope examination of the kidneys as a result of the diuretic, but only insignificantly. 3. There were signs of obstruction on standard radioisotope examination of the kidneys and they persisted also after administration of the diuretic. These results of dynamic scintigraphy of the kidneys using a diuretic make it possible to differentiate more readily dilatation of the upper urinary pathways in the absence of an obstruction from dilatation due to a significant obstruction, which is important when deciding on further diagnostic and therapeutic procedures in clinical urological practice.

Adolescent↗

PubMed1989

[Magistral preparation of methylene diphosphonate and its clinical evaluation in radionuclide diagnosis of the skeleton].

The present authors report on their own method of preparation of a frozen kit of methylenediphosphonate (MDP) which has been hitherto imported from the foreign currency area. The preparation after labelling with 99mTc serves for scintigraphy of the skeleton. The rate of MDP and the reducing reagent (SnCl2.2H2O)-5:1 proved to be the most advantageous. The preparation was compared with two more radiopharmaceuticals: hydroxyethylidenedisphosphanate (HEDP) and pyrophosphate (PYP). The results of a subjective evaluation of readability of scintigrams with grades 1-5 are unequivocally more favourable for MDP and HEDP (2.3 and 2.4) against PYP (3.1). MDP possessed the best rate of the number of impulses from the bone and the surrounding tissue--the background of the radiopharmaceuticals under study. The authors also examined the rapidity of uptake of MDP in the bone, kidney and its elimination from the plasma. The obtained results were in good agreement with commercial preparations tested at different laboratories. The use of MDP prepared in this manner is a contribution both to economy and clinical practice.

Bone and Bones↗

PubMed1989

[Radionuclide examination of kidney function in children with vesico-renal reflux].

The authors report on their experience with the assessment of radionuclide, separated renal clearance in children with unilateral vesicorenal reflux. The radiopharmaceutical preparation 131I-orthoiodohippuran was used, the result of the examination was a separated effective renal plasma flow (ERPF) which was assessed according to a modification of Oberhausen's method. A total of 28 children were examined. In 8 children the vesicorenal reflux was grade III and IV, in 20 children a unilateral grade II vesiculorenal reflux was involved. In both groups the authors demonstrated a significant functional deficit (p less than 0.001) of the kidney with the reflux despite the fact that in the second group all children had normal excretory urography, a negative urinary sediment and a normal creatinine and urea blood level.

Child↗

PubMed1988