[Study on drugs of the anthraquinone series. XIX. The determination of the sennosides C and D].
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Aloe↗
Biomedical subjects
J Lemli
Publications and source records attributed to J Lemli.
[Research on drugs with anthraquinone bases. XIV. Isolation of a new heteroside from Senna leaves: diglucoside of aloe emodin dianthrone].
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Aloe↗
[New heterosides of fresh bark of Rhamnus frangula L].
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Chemistry, Pharmaceutical↗
Direct and indirect evidence for the involvement of prostaglandins in the secretagogue action of rhein anthrone in the small intestine.
The present study was undertaken to investigate the involvement of prostaglandins in the secretagogue action, observed after intraduodenal administration of rhein anthrone and rhein in rats. After intraduodenal administration of rhein anthrone (50 mg/kg), the active metabolite of sennosides, a very marked increase of secretion was observed compared to control. The amount of secretion was calculated by dividing the total weight of the small intestine, obtained 30 minutes after administration of the drug, by the total length. The effect seen with rhein (50 mg/kg) is far less pronounced than that with rhein anthrone and is not significant when compared with control. Pretreating the animals with indomethacin (15 mg/kg, p.o., 1 hour in advance) or with ibuprofen (15 mg/kg, p.o., 1 hour in advance) largely prevents the secretagogue effect of rhein anthrone, suggesting that prostaglandins play an important role in the observed pharmacological action. This idea is reinforced by the observation that pretreatment with hydrocortisone (50 mg/kg, p.o., 6 hours in advance) is also able to counteract the effect of rhein anthrone. After administration of rhein anthrone, an almost tenfold increase of the tissue content of prostaglandin E2 was observed. Here again, the results with rhein were far less pronounced. It is concluded that prostaglandins play an important role in the secretagogue action of rhein anthrone.
Animals↗
[Comments on the monographies of drugs of botanical origin of the European Pharmacopoeia (Volume I and II) (author's transl)].
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Europe↗
[The mechanism of action of sennosides].
A review of the recent progress in the study of the mode of action of the sennosides, the active constituents of the senna drug, is presented. An interaction between rhein anthrone, the active metabolite of the sennosides, and the immune cells of the colon is suggested as a base for laxative activity.
Animals↗