A 9-year-old child was found to have massive invasion of his bone marrow by malignant cells. Experienced pathologists were unable to determine on morphological grounds the nature of these cells, even after electron microscope study and multiple cytochemical staining of bone marrow smears. However, serological analysis of the cells showed that they displayed an antigen specific to cells from common acute lymphoblastic leukaemia HLA-DR antigens and contained high concentrations of terminal deoxynucleotidyl transferase. A course of the chemotherapy usually prescribed for common acute lymphoblastic leukaemia resulted in complete remission.

Child↗

PubMedDate not supplied

[Principle products used in chemotherapy. Administration methods].

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Antineoplastic Agents↗

PubMedDate not supplied

[Sympathoma and diarrhea caused by hypersecretion of vasoactive intestinal peptide (VIP). Apropos of a further case].

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Child, Preschool↗

PubMedDate not supplied

[Diagnosis and evaluation of cervico-facial cancers in children].

Malignant neoplasia of head and neck in children are mostly embryonal sarcoma and non Hodkgin's lymphomata. Squamous-sell carcinomas are only 10%. The main locations are in nasopharynx and paranasal sinuses. Symptoms are corelated with location of the primary. Treatment depends of the pathologic type. Combination of chemotherapy and radiotherapy, and sometimes surgery, yield now more cured patients, especially in embryonal sarcoma.

Carcinoma, Squamous Cell↗