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Biomedical subjects

J Leigh

Publications and source records attributed to J Leigh.

At least 55 records · Page 3Linked to original sources
PubMed1986

Myocardial high energy phosphate metabolism in closed chest dog: creation of an animal model.

A chronic closed chest dog model was developed to study myocardial metabolism with NMR spectroscopy. Cardiac windows were surgically created in 10 dogs by removal of two ribs and accompanying skeletal muscle. Marlex mesh was sewn between the two exposed ribs, and fascia and skin were closed. 31P spectra were obtained using a surface coil placed into the surgically created pouch and using routine NMR pulsing techniques.

Adenosine Triphosphate↗
PubMed1986

Total population study of factors affecting chronic bronchitis prevalence in the coal mining industry of New South Wales, Australia.

The period prevalence of simple chronic bronchitis (SCB) (mucus hypersecretion), defined as chronic cough and sputum production by the MRC respiratory symptom questionnaire administered by occupational physicians and of obstructive chronic bronchitis (OCB) (airflow obstruction) (defined as SCB plus FEV1 less than 80% predicted) have been measured over the period 30 June 1977-30 June 1980 in the entire work force aged between 21 and 60 of the coal industry of New South Wales, Australia (12 357 men). Four dimensional contingency table analysis by a logistic transform method showed highly significant (p less than 0.001) additive affects of age (exposure duration), site of work, smoking, and alcohol consumption on development of overall chronic bronchitis (SCB + OCB). Odds ratios were face work:surface work = 1.78:1, smoker:non-smoker = 4.23:1, alcohol greater than 300 g/wk:alcohol less than 300 g/wk = 2.13:1. There was no evidence for synergistic effects of these factors on the development of mucus hypersecretion. When OCB was analysed separately, the effect of site of work, although in the same direction, was not statistically significant and this was assumed to be due to a "healthy worker" effect or a "swamping" effect of smoking. Age, smoking, and alcohol effects were highly significant (p less than 0.0001) and there was a sharp increase in prevalence of OCB in the age groups 41-50 and 51-60. Odds ratios were face work:surface work = 1.11:1, smoker:non-smoker = 2.66:1, alcohol greater than 300 g/wk:alcohol less than 300 g/wk = 2.91:1. There was no evidence of synergistic effects. These results are consistent with a hypothesis of additive effects of smoking, alcohol, and coal mine dust and fumes on the development of chronic mucus hypersecretion leading to airflow obstruction or a hypothesis of similar additive effects on the development of two separate conditions--mucus hypersecretion with airflow obstruction and mucus hypersecretion without airflow obstruction.

Adult↗
PubMed1986

Amniocentesis and the management of premature labor.

Two applications of amniocentesis for the evaluation of the patient in idiopathic premature labor, fetal lung maturity testing, and detection of occult intraamniotic infection were evaluated in a review of 59 cases. Seven patients (12%) had positive amniotic fluid cultures despite the absence of clinical signs of infection. This group presented at earlier gestational ages (29 + 2.3 versus 32 + 2.0 weeks, P less than .005) and were more likely to rupture membranes while on tocolytic therapy (four of seven versus two of 52, P less than .001) than patients whose cultures were negative. All seven patients with a positive culture delivered within 48 hours of admission, whereas 44 of 52 patients with negative cultures delivered after 48 hours (P less than .001). Increase in maternal and neonatal morbidity seemed to be related primarily to a higher cesarean section rate and earlier gestational ages at delivery in this group. Lecithin/sphingomyelin ratio was predictive of fetal lung maturity as expected. More than one-half of patients greater than 33 weeks and one-third of patients at 31 to 32 weeks demonstrated fetal lung maturity. The authors conclude that amniocentesis is an important tool in evaluating patients in preterm labor, especially with respect to making appropriate management decisions regarding tocolytic and/or corticosteroid therapy.

Adrenal Cortex Hormones↗
PubMed1978

Contacts among patients with hematological malignancies.

A survey was carried out in 2 country areas of New South Wales with the aim of defining contacts among patients with lymphoma, leukemia and myeloma, and of determining whether these were more numerous than among matched controls from the same localities. Cases were identified from records of the N.S.W. Central Cancer Registry and of local doctors and hospitals. 184 cases were found, corresponding to the expected number, and 145 patients, as well as the same number of controls, were interviewed. Of the 290 patients and controls surveyed 111 (38.3%) had had one or more contacts with other patients or controls (37.9% of patients and 38.6% of controls). There were 24 case-case pairs involving contacts among 33 individual patients, 23 control-control pairs involving 36 individuals, and 38 case-control pairs involving 66 individuals. A statistical analysis using a weighting system showed that numbers, closeness and duration of contacts among patients and patients did not differ significantly from those expected. These results thus provide no evidence in favor of the hypothesis that the diseases were transmitted from patient to patient in the survey areas.

Australia↗
PubMed1976

Health service computer applications in Australia.

An evaluation of some medical computer applications is presented. Some comparison is made with the British National Health Service. The medical computing systems that are operating are discussed for both their obvious merits, and some of the difficulties and problems facing them. To keep the high standard that Australia enjoys in this field, a coordinated policy of development and constant evaluation of established projects should be maintained.

Australia↗