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Biomedical subjects

J Lefebvre

Publications and source records attributed to J Lefebvre.

At least 343 records · Page 19Linked to original sources
PubMedDate not supplied

Stimulation of DNA synthesis by prolactin in human breast tumor explants. Relation to prolactin receptors.

Breast-cancer tissue from 38 patients was tested for prolactin sensitivity by measuring both 16-hour (3H)dT incorporation in tissue fragments during 24-hour organ cultures, and prolactin receptors in tumor specimens. We observed a stimulation of DNA synthesis by prolactin in 6/38 (16%) cases; the stimulation was maximum with physiological concentrations of prolactin (0.05 to 0.2 microgram/ml medium). The stimulation of DNA synthesis never occurred in the absence of prolactin receptors. There is no relation between the response to prolactin and estradiol or progesterone receptor levels, but in four cases the stimulation was observed when the three receptors were present. Finally, the response to the stimulation was independent of the clinical stage of the patient.

Breast Neoplasms↗
PubMedDate not supplied

[The thyroxine hyperthyroidism (author's transl)].

24 of all patients observed between 1974 and 1976 suffering from thyrotoxicosis were found to have increased blood thyroxine (T4) levels without increased triiodothyronine ones. T4 hyperthyroidisms represented 3.5% of all hyperthyroidisms observed; they were in relation with Grave's disease (18 patients) or toxic nodular (6 patients); clinical pictures were quite usual; old age, severe illnesses, amiodarone and corticoids treatments, iodine excess, were sometimes being incriminated, but often no particular cause could be found. Preferential T4 secretion or impaired peripheral T4 conversion are two possible mechanisms of T4 hyperthyroidism.

Adult↗
PubMedDate not supplied

Treatment of undernutrition and electrolyte disturbances in anorexia nervosa.

Medical care of undernutrition and hydro-electrolytic disturbances in anorexia-nervosa differs according to the stage of weight loss, as appreciates through "corpulence index". In each case, it will depend on a precise appreciation of biological data, mainly hydro-electrolytic ones. One has to particularly stress the frequence of hypochloremic-hypokalemic alkalosis which must be treated by isotonic saline perfusion till the normalisation of plasma electrolytes. Refeeding can be achieved either by oral, parenteral or nasogastric tube: this last method being, in our hand, the most successful. The results of short-term treatment is often good; however the prognosis of long term treatment largely depends on the specific care for psychological disturbances.

Alkalosis↗