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Biomedical subjects

J Leeton

Publications and source records attributed to J Leeton.

90 records · Page 5Linked to original sources
PubMedDate not supplied

The establishment and maintenance of pregnancy using in vitro fertilization and embryo donation in a patient with primary ovarian failure.

Ovarian steroid replacement therapy in the ovariectomized ewe, given in the correct sequence to mimic endogenous steroid changes in the normal ovulatory cycle, allows the development of embryos transferred in utero. A similar type of sequential therapy was designed for steroid replacement in women with primary ovarian failure. This produces the histological changes in uterine endometrial morphology and plasma oestradiol and progesterone similar to those observed in the normal ovulatory cycle. We now report that in one of these women a donated oocyte, fertilized by her husband's spermatozoa and cultured to the two-cell stage in vitro, was transferred in utero, resulting in a normal pregnancy and the delivery of a healthy child. Oestrogen therapy was withdrawn at 12 weeks and progesterone at 19 weeks gestation. This technique allows the treatment of human infertility due to primary ovarian failure.

Embryo Transfer↗
PubMedDate not supplied

The diagnostic value of in vitro fertilization and embryo transfer.

Besides the well known indications for the use of IVF as a new therapeutic treatment, this technique may also be used as a diagnostic test for infertile couples in whom pregnancy was not achieved by previous treatments. IVF diagnostic test appears to be very reliable in the majority of cases. If the failure of fertilization occurs in the first attempt the test is not reliable; failure of fertilization after three or more attempts allows the patients to consider other options such as adoption or AID.

Adult↗