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Biomedical subjects

J Leeton

Publications and source records attributed to J Leeton.

At least 37 records · Page 2Linked to original sources
PubMed1988

Sister-sister in vitro fertilization surrogate pregnancy with donor sperm: the case for surrogate gestational pregnancy.

A case of surrogate pregnancy is described in the sister of a 40-year-old hysterectomized woman where two oocytes of the latter were fertilized in vitro with known donor sperm and transferred into the surrogate. A normal singleton pregnancy developed which was complicated after 24 weeks of gestation with recurrent antepartum hemorrhages due to grade 3 placenta praevia. A healthy female baby was delivered by elective cesarean section at 36 weeks of gestation. The legal, social, psychological, and ethical issues of surrogacy remain unsettled and are discussed in this case report.

Adult↗
PubMed1988

Successful pregnancy in an ovulating recipient following the transfer of two frozen-thawed embryos obtained from anonymously donated oocytes.

A fertile woman suffering from mild dystrophia myotonica had undergone sterilization because of the 50% genetic risk of this disease developing in her offspring. In her second treatment cycle on the donor oocyte program, four anonymously donated oocytes were inseminated with frozen-thawed sperm of her husband. Three embryos were obtained and two surviving embryos were deep-frozen at the eight-cell stage and kept in storage for 9 months. These embryos were successfully thawed and transferred to the recipient 97 hr after the onset of her luteinizing hormone surge. A normal singleton pregnancy developed and a healthy male infant was delivered by cesarean section at 36 weeks of gestation.

Adult↗
PubMed1988

Nonsurgical management of unruptured tubal pregnancy with intra-amniotic methotrexate: preliminary report of two cases.

Two cases of unruptured tubal pregnancy were managed conservatively by the aspiration and injection of 50 mg methotrexate into the amniotic sac with the use of a vaginal ultrasound transducer under local anesthesia. Both women experienced no pain or side effects and went home within 12 hours. Spontaneous menstruation began in both cases within 6 weeks of the procedure.

Adult↗
PubMed1988

Ultrasound-guided fallopian tube catheterization per vaginum: a feasibility study with the use of laparoscopic control.

The fallopian tube can be cannulated per vaginum under ultrasound control. The sensation and ultrasound appearance of smooth passage without visible kinking are accurate predictors of success. The average time taken for each cannulation was 7.2 minutes. Adequate practice in non treatment cycles is essential before proceeding to cell transfer, while further modification of the catheters used may improve overall success.

Adult↗
PubMed1987

Transfundal transfer of embryos using ultrasound.

Ultrasonically guided transfer of embryos was performed transabdominally in 10 patients. The uterus was punctured by a 16-gauge needle with a stylet through a full urinary bladder. When the needle tip was in the uterine cavity the stylette was removed and a transfer catheter loaded with the embryos was inserted. No complications or technical difficulties were experienced. None of the patients became pregnant.

Adult↗
PubMed1987

Evaluating the possibility of uterine transfer by ultrasonically guided transabdominal puncture.

Ultrasonically guided transvesical puncture of the uterine endometrial cavity was carried out in 16 patients to evaluate the feasibility of embryo transfer by this procedure. Instillation of fluid into the uterine cavity was achieved in all cases and easily performed in 15 patients. In one patient the fundal endometrium was reached in the third attempt. Instillation of fluid within the endometrium was attempted unsuccessfully in four patients, as the fluid leaked into the uterine cavity. In 12 patients 2-4 ml of fluid was injected. The fluid passed down through the cervix in patients in the luteal phase (nine patients) when 3 ml or more was injected. When a smaller amount of fluid was instilled it remained inside the cavity. In one patient in the preovulatory phase the fluid was actively pumped by uterine contractions into the vagina. Two cases in the proliferative phase showed no leakage from the cervix when 1.5 and 2 ml of fluid was injected, respectively.

Embryo Transfer↗
PubMed1987

Transvaginal recovery of oocytes for in vitro fertilization using vaginal ultrasound.

Vaginal recovery of oocytes for in vitro fertilization (IVF) was performed in 75 patients using a vaginal puncture transducer. Follicles were aspirated and flushed four times using a controlled vacuum. Oocytes were collected in 74 patients and an average of 5.1 oocytes was collected per patient. An average of 8.8 follicles was aspirated per procedure, giving an oocyte recovery rate of 58% per follicle. Pregnancy was obtained in seven patients (9.3%). The only complication was bleeding from the vagina of an estimated 40 ml in one case.

Cell Separation↗
PubMed1987

A controlled study between the use of gamete intrafallopian transfer (GIFT) and in vitro fertilization and embryo transfer in the management of idiopathic and male infertility.

A randomized controlled trial comparing the use-effectiveness between gamete intrafallopian transfer (GIFT) and in vitro fertilization (IVF) and embryo transfer (ET) procedures showed no significant difference in pregnancy rates in the management of patients presenting with idiopathic or male infertility. The cost-effectiveness of GIFT appears superior to IVF and ET with laparoscopic oocyte collection, but comparable to IVF-ET with ultrasonic oocyte collection. The lack of data on the fertilizing capacity of sperm in GIFT procedures in cases of male infertility is a real disadvantage and currently precludes the management of severe male infertility with this method.

Adult↗
PubMed1987

The donation of oocytes to known recipients.

The supply of donated oocytes from an in vitro fertilization programme has always been inadequate, especially following the successful cryopreservation of human embryos. There have been no previous reports of women donating their oocytes to known recipients. All of 7 women who donated all their oocytes to known recipients responded to a posted questionnaire. No differences in social characteristics between this group and another group of infertile women treated on an in vitro fertilization programme, who donated some of their excess oocytes anonymously were noted, except that the known donor group had a relatively high average parity, i.e. 3. No differences in attitudes towards donating oocytes were noted between these groups except that the known donor group felt a significantly greater connection towards the potential child.

Adult↗
PubMed1986

Attitudes toward egg donation of thirty-four infertile women who donated during their in vitro fertilization treatment.

The attitudes of anonymous infertile egg donors treated on an in vitro fertilization program toward the donation, the recipient, the potential children conceived, and the recording of information were explored by posted questionnaire. All donations were made for altruistic reasons and payment of eggs was not expected or given. The majority of donors (91%) wished to withhold their names from the recipient, but half of the donors would not mind if the child contacted them later. Most donors (94%) had told others of their donation and the keeping of records would appear essential for future possible identification. Some possible differences in attitudes between egg and sperm donors were noted but comparisons are difficult due to basic differences in fertility status and ease of gamete collection. The attitudes and characteristics of a control group of infertile women, who were in a position to donate excess eggs but declined, showed no significant differences from those of the donor group, except that they had a significantly greater number who already had one or more children and were less likely to discuss their possible donation with others.

Attitude↗
PubMed1986

Pregnancy established in an infertile patient after transfer of an embryo fertilized in vitro where the oocyte was donated by the sister of the recipient.

A successful pregnancy in a patient suffering from infertility due to severe tubal disease has been achieved following the transfer of embryos fertilized in vitro following the donation of oocytes by the sister of the recipient. Both sisters ovulated irregularly and asynchronously. The donor's menstrual cycle varied from 24 to 30 days and the recipient's cycle varied from 23 to 26 days. Synchronization of ovulation was achieved by matching the onset of their menstrual cycles prior to treatment by in vitro fertilization and by manipulating the follicular phase of both the donor and the recipient during the cycle of treatment. Ten oocytes were collected from the donor and all were inseminated with spermatozoa from the recipient's husband. Nine normal embryos developed and three were transferred to the uterus of the recipient sister, 55 hr after laparoscopic egg collection. A normal singleton pregnancy resulted.

Embryo Transfer↗