Physical exercise and carbohydrate and lipid metabolism.
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Biomedical subjects
Publications and source records attributed to J Lederer.
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In the male rat a diet rich in beef fat facilitates the occurrence of hyperinsulinemia after a glucose load whereas fats rich in linoleic acid produce no such effect. The combination of saturated fat and saccharose facilitates the occurrence of hypertriglyceridemia in the male rat, no such effect is produced by the combination of fats rich in linoleic acid and saccharose. Linoleic acid prevents natrium chloride from provoking hypertriglyceridemia in male and in female rats subjected to a diet enriched in saccharose and fat. Estrogen-induced hypertriglyceridemia in castrated animals is strongly inhibited if the diet is rich in linoleic acid. Physical effort can prevent saccharose combined with saturated fats from inducing hypertriglyceridemia.
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In the male rat, sorbitol, beef fat nor M.C.T. in the diet provoke hypertriglyceridemia but the association sorbitol-beef fat and sorbitol-M.C.T. significantly rise the triglyceridemia and the cholesterolemia. In the castrated male rat estrogens provoke a considerable rise of the triglyceridemia and the cholesterolemia with the diet enriched in M.C.T. but not modify the hypertriglyceridemia and the hypercholesterolemia provoked with the diet enriched with the association sorbitol-T.C.M.
Neo natal androgenisation of the female rat provoke at 3 months : 1) an accentuation of the insulin secretion at the glucose loading with the diet rich in saturated fat an a reduction with the diet rich in sucrose or rapesced oil; 2) Hypercholesterolemia with all the diets and 3) hypertriglyceridemia with diet rich in saturated fat or sucrose. Neo natal oestrogenisation of the male rata provoke at 3 months : 1) a reduction of the insulin secretion at the glucose loading with all the diets 2) hypercholesterolemia with the diet rich in saturated fats 3) hypertriglyceridemia with diets rich in M.C.T. or sucrose.
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