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Biomedical subjects

J Lausmaa

Publications and source records attributed to J Lausmaa.

26 records · Page 2Linked to original sources
PubMed1990

Method for ultrastructural studies of the intact tissue-metal interface.

Samples were prepared for ultrastructural studies of the intact interface between metallic implants and tissue by transmission electron microscopy. The method is based on plastic embedding of implant and tissue and subsequent removal of the bulk metal by electrochemical dissolution (electropolishing), to facilitate preparation of ultrathin sections for transmission electron microscopy. Surface sensitive spectroscopy (Auger electron microscopy and X-ray photoemission spectroscopy) and transmission electron microscopy EDX results show that the method produces samples with an intact interface, containing the implant surface oxide and the adjacent tissue. Examples of application of the method on titanium, zirconium and aluminium implants in soft tissue are given.

Aluminum↗
PubMed1989

Ultrastructural differences of the interface zone between bone and Ti 6Al 4V or commercially pure titanium.

Commercially pure (CP) titanium and Ti 6Al 4V alloy were sputtered onto polycarbonate plastic implants to analyse hard tissue reactions to the two metals. The implants were inserted in the tibial metaphyses of five rabbits. Three months later they were removed and processed for light microscopy (LM) and transmission electron microscopy (TEM) investigations. At the LM level, disordered woven bone was seen in the interface zone of Ti 6Al 4V, whereas organized bone was observed in direct contact with the CP titanium implants. TEM examination of Ti 6Al 4V sections revealed a 500-1000 A thick collagen-free proteoglycan layer compared to 200-400 A for CP titanium. A surface analysis test was performed to compare the magnetron sputtered film with bulk Ti 6Al 4V alloy. This test revealed no major differences between the experimental implant and the bulk alloy. More natural-like tissue reactions were observed to CP titanium than to Ti 6Al 4V alloy.

Alloys↗
PubMed1988

Biomaterial and implant surfaces: on the role of cleanliness, contamination, and preparation procedures.

Material specificity in implant-tissue interactions derives primarily from the surface properties (chemical composition, microstructure, etc.) of the implant. This article addresses several questions related to implant and biomaterial surfaces: What is the status of real implant surfaces (composition, cleanliness, contamination, microstructure, etc.), and how does it vary with preparation procedures? Can the surface status be varied and analyzed in a controlled manner? How significant are surface status variations for in vivo function? And so on. We discuss clean surfaces, how they are contaminated, and how the contamination may affect the properties. We also discuss different preparation procedures, such as conventional machining, plasma treatment, and sterilization. Three important conclusions are drawn: (i) The surface status of a particular implant material may vary widely depending on its preparation and handling history. (ii) The surface status of implants is expected to be important for in vivo function, and should thus be controlled and standardized. (iii) It is usually not possible to predict how a change in surface status will affect the long-term, in vivo function of an implant.

Biocompatible Materials↗
PubMed1988

Surface spectroscopic characterization of titanium implants after separation from plastic-embedded tissue.

The method of plastic embedding of tissue and implant and subsequent separation of plastic and implant for preparing sections of tissue adjacent to solid metallic implants relies on a successful separation of the embedment and the implant. In this work, the surface of machined Ti implants has been analysed in order to investigate to what extent plastic remnants exist on the implant after separation. SEM and AES analyses show that at least 70% of the implant surface is free of plastic remnants to a proximity of 10 nm or less from the implant surface. The method is simple and suitable for both light and transmission electron microscopy of the interface tissue.

Bone Screws↗
PubMed1986

Characterization of surface roughness in titanium dental implants measured with scanning tunnelling microscopy at atmospheric pressure.

Characterization of the surface topography of implant materials is important for understanding tissue response. We have measured, for the first time, the topography of titanium surfaces used in osseointegrated dental implants. Scanning tunnelling microscopy (STM) which provides 3D real space images was used. In addition to clinical samples, electropolished and anodically oxidized surfaces were also measured. Clinical samples are rather inhomogeneous in character showing grooves and steps with a maximum depth of 0.11 micron. Micropores with an average diameter of about 30 nm are also present. Electropolished samples are rather homogeneous and very smooth, showing steps of 1 to 5 nm in height. The measurements were performed under atmospheric conditions at a resolution in the subnanometer range.

Dental Implantation, Endosseous↗
PubMed1985

Accelerated oxide growth on titanium implants during autoclaving caused by fluorine contamination.

Titanium implants were occasionally found to be strongly discoloured after autoclaving. The discolouration is shown to be due to an accelerated growth of the surface oxide that covers the implants. Oxide thicknesses up to 650 A have been observed, i.e. more than ten times thicker than on normal implants. By applying surface sensitive spectroscopies (SIMS and XPS or ESCA) it is also shown that these oxide films contain considerable amounts of fluorine, alkali metals and silicon. Screening tests with alkali-halide solutions identify fluorine as the impurity responsible for the accelerated oxide growth. Discolouration after autoclaving can be observed for fluorine contaminations down to the ppm level. In those cases where discolouration was observed in the clinical situation, the source of fluorine was the textile cloths in which the titanium implant storage box had been wrapped during the autoclaving procedure. The cloths contained residual Na2SiF6 which had been used as an additive to the rinsing water used in the last step of the cloth laundry procedure. Since the biocompatibility of titanium implants is closely related to their surface oxides it is advisable to avoid all sources of fluorine in the implant preparation procedures.

Color↗