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Biomedical subjects

J Larsen

Publications and source records attributed to J Larsen.

At least 109 records · Page 6Linked to original sources
PubMed1991

Effects of dobutamine and salbutamol on haemodynamics and atrial natriuretic factor in patients with severe congestive heart failure.

The influence of two cardiac inotropic drugs, dobutamine and salbutamol, on plasma atrial natriuretic factor (ANF) was investigated in 20 patients with congestive heart failure. All were in New York Heart Association class-III or IV. The patients underwent right heart catheterization with determination of central pressures, cardiac output, and pulmonary arterial plasma ANF during incremental infusions with dobutamine or salbutamol. Fourteen patients completed the study. Both drugs induced comparable increases in cardiac index and decreases in total systemic vascular resistance (P less than 0.01) without significant changes in central pressures. Heart rate rose after salbutamol (P less than 0.05), but not after dobutamine. No changes in plasma ANF were observed after either of the drug infusions. ANF secretion rate was calculated from simultaneous measurements of ANF in right atrial and pulmonary arterial plasma before and after salbutamol infusion, and median values rose more than seven-fold (P less than 0.05). The results demonstrate that ANF secretion rate is augmented after beta-adrenergic agents, possibly by a direct beta 2-adrenergic stimulation, in patients with severe congestive heart failure, and that changes in plasma ANF are an insufficient measure of ANF release when patient samples are small.

Adult↗
PubMed1991

Systemic interferon alpha-2b increases the cure rate in laser treated patients with multiple persistent genital warts: a placebo-controlled study.

Systemic treatment modalities for eradication of multiple therapy resistant genital warts are so far not available. In this study laser treated patients with multiple genital warts received postoperatively either interferon alpha-2b subcutaneously (s.c.) 5 x 10(6) IU or matching placebo three times weekly for four weeks. At the conclusion of the study, 6-8 weeks after discontinuation of therapy, a significantly higher cure rate was found in the group of interferon-treated patients (14 of 27 (52%) patients cured) than among placebo treated patients (5 of 22 (23%) patients cured) (p less than 0.05). The side effects of fever, chills, myalgia, headache and leukopenia occurred more commonly in the interferon treated group than in the placebo group. However, only three of 32 patients discontinued interferon therapy because of side effects. We conclude that the addition of s.c. administered interferon alpha-2b to laser treated patients with chronic therapy resistant genital warts is fairly well tolerated and that it significantly enhances the chance of eliminating the disease.

Adult↗
PubMed1991

Analysis of Ni(2+)-induced arrest of Paramecium axonemes.

This study examines the molecular basis for paralysis of ciliary motility by Ni2+. At concentrations above 0.1 mM, Ni2+ slowed and subsequently stopped swimming of living, axenically grown Paramecium tetraurelia. However, some cilia still beat in the presence of 0.1 mM Ni2+. When permeabilized and reactivated with 4 mM ATP at pCa greater than 7, cells resumed ciliary beat and swam forward at approximately 170 +/- 28 microns s-1; swimming speed increased in the presence of 10 microM cyclic AMP. Addition of Ni2+ (pNi less than 5) caused rapid arrest of all ciliary beat in a single position. This was fully reversible when EGTA was added to raise the pNi. Axonemes were then isolated and sliding was observed in the presence of trypsin and ATP. When pNi was lowered to about 5, sliding was reduced dramatically. This too was reversible with EGTA. Dynein was then extracted from the axonemes and used for in vitro translocation assays. At concentrations of Ni2+ where microtubule-sliding and axonemal beat were greatly inhibited or absent, microtubule translocation in vitro by 22 S dynein was only slightly affected. However, translocation by 14 S dynein was stopped completely. When pNi was raised by repeated washing with solutions containing EGTA, microtubule translocation by 14 S dynein resumed. We conclude that Ni2+ induces a reversible paralysis by a direct effect on 14 S dynein while 22 S dynein is not a primary target.

Adenosine Triphosphatases↗
PubMed1991

Subclinical human papilloma virus infection in condylomata acuminata patients attending a VD clinic.

In 37 (77%) of 48 patients with external genital warts, application of 5% acetic acid revealed areas of acetowhite epithelium. The lesions were not clinically apparent before acetic acid was applied but were easily detected without the use of a colposcope. In a control group of 20 patients with chlamydial urethritis and no history of genital warts, none had acetowhite genital lesions. Histological examination of biopsy specimens from the flat acetowhite lesions showed HPV infection with koilocytosis in 29 (78%) and in 3 (8%) intra-epithelial neoplasia grade II-III. Using in situ hybridization with commercially available biotinylated DNA probes, HPV types 16/18 could be detected in 7 (24%) patients with koilocytosis and in 3 (100%) patients with dysplasia. Simultaneous infection with HPV types 6/11, 16/18, and 31/33/35 was found in 8 of the 13 HPV DNA-positive patients. It is concluded that subclinical HPV-induced acetowhite lesions are common among patients with genital warts and that these flat lesions may be associated with a high grade of dysplasia. Consequently, routine use of the acetic acid test on the genital epithelium is recommended in patients with condylomata acuminata in order to diagnose and treat all HPV-infected areas.

Ambulatory Care Facilities↗
PubMed1990

[Information to women applying for sterilization].

On the basis of a questionnaire investigation among the general practitioners in the County of Frederiksborg, the authors have compared the information given to women applying for sterilization with information in the available literature about the nature of the intervention, its sequelae and the risks involved. The authors found that under half of the practitioners gave informations about disturbances of menstruation, dyspareunia and altered sexual life. In the literature, it is stated that these occur in 10-60%, 3-11% and 4-48% of the women. Less than one third of the practitioners gave information about the risk of perforation of an organ or vessels, tearing of the ovarian tubes and postoperative pain. In the literature, it is stated that these occur in 0.1-2.5%, 0.28-9% and 24% of the women depending on the operative method used. The authors recommend revision of our knowledge on these subjects and alterations in the written information provided.

Denmark↗
PubMed1990

[Unwanted pregnancy after removal of the IUD].

Four cases of unwanted pregnancy occurring in the same cycle as removal of an IUD are presented. The duration of ovum transport from the Fallopian tube into the uterine cavity, survival of spermatozoa in the female genital tract and timing of ovulation, which may be delayed in women with IUDs are variables which influence the probability of pregnancy and should be taken into consideration when removing an IUD. Unless pregnancy is desired, it is recommended when possible not to remove an IUD after the ninth day of the menstrual cycle unless another contraceptive method has been initiated.

Adult↗
PubMed1990

[Human papillomavirus (HPV) vulvitis].

Human papilloma virus vulvitis with flat elements resembling leucoplakia may be diagnosed by application of a 5% acetic acid solution and subsequent biopsy and histological examination. The condition causes irritation with dyspareumia and is so frequent that the diagnosis and initial treatment may be undertaken by the general practitioner.

Adult↗
PubMed1990

[Lack of precision of measurements with neonatal thermometers].

Seventy Uebe's mercury neonatal thermometers were checked in a thermostatically-controlled water bath to detect possible errors in measurement. Sixteen out of 18 old neonatal thermometers showed gross errors of measurement with a maximal deviation of +5.31 degrees C. Out of 52 recently issued neonatal thermometers, only 27 (52%) fulfilled the requirements for correction of maximally 0.10 degree C established by the Danish Ministry of Health. The remaining 25 neonatal thermometers presented lesser errors with a maximal deviation of -0.30 degrees C. Employment of Uebe's mercury neonatal thermometer can thus only be recommended after meticulous testing of the thermometers prior to use and with continued regular control of the accuracy of temperature measurements.

Diagnostic Errors↗
PubMed1990

Posttransfusion hepatitis B transmitted by blood from a hepatitis B surface antigen-negative hepatitis B virus carrier.

A female blood donor at our institution was implicated in three cases of clinical posttransfusion hepatitis B. She had given blood 25 times in 8 years. Twenty-seven recipients were followed up, and about one-half of those who were still living had serologic markers of hepatitis B virus (HBV) infection. The donor was repeatedly negative for hepatitis B surface antigen (HBsAg) and antibody, but she had high titers of antibody to hepatitis B core antigen. We conclude that blood from this HBsAg-negative blood donor was capable of transmitting hepatitis B.

Blood Donors↗
PubMed1990

The patient with refractory genital warts in the STD-clinic. Treatment failure with CO2-laser.

Sixty two patients with refractory genital warts attending a VD-clinic were treated with CO2-laser. Residual warts or new wart formation was observed in 45 of them (72%), two weeks after operation, resulting in an immediate cure rate of 27%. The cure rate obtained was independent of location, duration, and previous treatment of warts. Reoperation with CO2-laser was performed in 12 patients, and all had remaining lesions two weeks after operation. It is concluded that a single CO2-laser treatment often is an insufficient procedure for eradication of disseminated refractory genital warts.

Adult↗
PubMed1990

Interferon alpha-2b dependent recalcitrant genital warts.

Aggressive and chronic disfiguring large penile warts, where previous treatment had been unsuccessful, were flattened in a non-immunocompromised patient treated with interferon alpha-2b 5 x 10(6) I.U. subcutaneously three times a week. Cessation of therapy resulted in rapid recurrence of lesions, indicating persistence of the viral infection. Systemic interferon therapy, however, was the only remedy that could suppress the disease. Only transient and mild systemic toxicity was observed. Subcutaneously injected interferon alpha-2b should be considered in patients with otherwise therapy resistant large or disseminated genital warts.

Adult↗
PubMed1990

Prolonged application of acetic acid for detection of flat vulval warts.

Macroscopic visualization of flat vulval warts is usually obtained by application of 3-5% acetic acid for 2-5 min. However, we have recently seen two women with symptoms suggesting the presence of condylomatous vulvitis where the use of 5% acetic acid for 10-15 min. was necessary for aceto-white lesions to develop. In both women, histologic examination indicated the presence of a Human papillomavirus infection. Prolonged application of acetic acid 5% should be considered among women in whom vulval papillomavirus infection is suspected.

Acetates↗
PubMed1989

[Petroleum burns--toxic contact dermatitis].

A great proportion of older housing facilities in Copenhagen are occupied by elderly individuals whose flats are heated by petroleum stoves. These individuals have frequently reduced mobility and may risk falling while filling their stoves. They may thus be exposed to the effect of the toxic fluid on the skin. The clinical pictures in two cases are described.

Aged↗