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Biomedical subjects

J Lapierre

Publications and source records attributed to J Lapierre.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Seroepidemiologic study of toxoplasmosis in the school population of Sousse].

To obtain basic epidemiological data about toxoplasmosis in our area, we undertook a serological investigation of the female school population of Sousse City. 33% of the students in college (mean age: 17.8 years) are seronegatives. Social economic status seems not to be important for the risk of infection. The more important source of contamination may be the soil.

Adolescent↗
PubMed1983

[Congenital toxoplasmosis. Remarks apropos of serologic surveillance in 15,000 pregnant women].

The risk of acquired toxoplasmosis during pregnancy (1.2% of susceptible women) and of transmission of Toxoplasma gondii to the fetus (1% of neonates) was estimated from results of serial serological tests done in 15 132 pregnant women from 1977 to 1982. Congenital toxoplasmosis was studied in the product of 47 induced abortions and in 34 neonates. In aborted fetuses, congenital toxoplasmosis was established by serological tests in 3 cases and based on histological findings in 4. Among the neonates, 11 cases are reported; the 5 severe cases are due to early contamination.

Abortion, Induced↗
PubMed1983

[The peculiar features of Plasmodium vivax on the Cambodian-Thailand frontier (Sokh-Sann region)].

The authors report an untypical strain of Plasmodium vivax found in the area of Sokh-Sann (Thaï-Cambodian border). This strain is remarkable by: multiple infections and two chromatin dots occur commonly in the early trophozoite stage; the pigment is coarser and darker in the older stages, and Schüffner dots are seldom found. The incubation period is longer and the symptomatology more severe.

Cambodia↗
PubMed1983

[Treatment of 700 cases of bilharziasis with the new drugs oxamniquine, oltipraz, praziquantel].

The authors study the results of a treatment of 700 cases of bilharziasis seen in Paris and in two foci in Togo, by oxamniquine, oltipraz or praziquantel. The three drugs are well tolerated; only a few mild side-effects were reported such as discomfort, nausea, headaches (two cases of acrodynia with oltipraz ). The three drugs are very efficacious in the case of schistosomiasis mansoni (85,5% success rate with oxamniquine, 92,9% with praziquantel, from 76,5 to 92% with oltipraz depending on the different strains) at day 180. As far as schistosomiasis haematobium is concerned, oltipraz and praziquantel have a 87,5% success rate with oltipraz and 80% with praziquantel; however, in the case of oltipraz , it is necessary to increase the dose. The action of praziquantel seems to be slower on Schistosoma haematobium than on S. mansoni. By the study of the evolution of antibodies, the fast action of praziquantel was noticed, explaining the peak of serological titers and of eosinophilia as early as day 10 after treatment; in the case of oltipraz , the apparition of this peak is only recorded at the 30th day. The slower effect of oltipraz on worms implicates not to judge its efficacy by too early controls.

Adolescent↗
PubMed1982

[Dirofilariasis in humans. Report of a case with localization in the cheek (author's transl)].

Cutaneous dirofilariasis usually affects animals (dogs and cats) but can occur in human-beings. Occasionally, this cosmopolitan disease is seen in France. Our case-report is the sixteenth registered in France. The patient, a forty-two-year-old man, was infected in Corsica. He presented with a tumor of the right cheek from which a pregnant adult Dirofilaria (Nochtiella) repens was extracted.

Adult↗
PubMed1980

[Immunological diagnosis of echinococcosis. A study of 146 cases, including 8 with bone involvement (author's transl)].

After a study about 146 cases of echinococcosis which 8 osseous localizations, indirect immunofluorescence reactions and immunoprecipitation reactions allow for comparing between right immunologic answers in hydatid cyst of liver and hydatid cyst of bone. The right immunogenicity of osseous hydatid cyst can be explained by a close contact host-parasite and by a good vascularization and a good fertility.

Antibody Formation↗
PubMed1980

Preliminary report on the observation of a coronavirus in the intestine of the laboratory rabbit.

Intestinal infections are a major cause of mortality in domestic rabbits. Although a few pathogenic organisms have been associated with this type of infection, it is often impossible to demonstrate the presence of any etiologic agents. Recently viral particles were observed in the intestine of diseased rabbits submitted to our laboratory for diagnosis. A study was then initiated to evaluate the presence of viral agents in the intestine of rabbits showing clinical signs of enteritis. Viral particles with morphological characteristics of the Coronaviridae family were observed by electron microscopy in most specimens of fecal material obtained from sick rabbits. Such particles were not seen in the feces of healthy animals. These particles, which have a density of 1.07-1.18g/cm3 on sucrose gradient, hemagglutinate rabbit red blood cells. Furthermore this virus has some antigenic relationship with the human coronavirus 229-E since immune serum to this virus blocks the hemagglutination of the rabbit erythrocytes. Antibody titers to this virus were detected in rabbit sera obtained from colonies with a high incidence of intestinal infections. When fecal material containing coronavirus particles were inoculated on various tissue culture systems, no cytopathic effects were observed.

Animal Diseases↗
PubMed1977

[Recrudescence of imported malaria (author's transl)].

In the light of two recent cases of severe central nervous system malaria due to neglect in chemoprophylaxis, the authors report the very marked recrudescence in imported malaria and draw attention to the frequency of cases due to P. falciparum, the agent of malignant tertian fever and of malignant episodes. The necessity of early diagnosis in such cases is mentioned, together with the treatment of simple malaria and, in particular, of malignant varieties. In order to be effective, chemoprophylaxis must be begun immediately following arrival in an endemic area, continued regularly throughout the stay there and continued for 2 months after leaving. The blood of former malaria suffers, in order to avoid the risks of transfusion malaria, should be used only after seroimmunological studies have demonstrated the absence of anti-malaria antibodies.

Africa↗
PubMed1977

[Eosinophil ileitis (author's transl)].

Eosinophilic ileitis is observed mainly in three coastal areas: Holland, Japan and Brittany. It presents in the form of a parietal inflammation, stenosing the intestinal lumen or a sessile tumour of limited volume. The symptoms are generally those of appendicitis but a past history of allergy and the discovery of eosinophilia greater than 10 p. cent may lead to the diagnosis of eosinophilic granuloma which only histology can confirm. Surgical treatment consists of segmental resection of the small intestine. The pathogenesis of the granuloma, which was for long attributed to the presence in the wall of the intestine of ascaris larvae, is at present debated. Are there non-parasitic eosinophilic granulomas? The case reported here is perhaps an example.

Adolescent↗