Biomedical subjects
J Lapeyre
Publications and source records attributed to J Lapeyre.
Biological effect of transferrin on mast cell mediator release during the passive cutaneous anaphylaxis reaction: a possible inhibition mechanism involving iron.
A purification procedure for passive cutaneous anaphylaxis inhibitory factor from BALB/c mouse serum has been previously described. In the present work, this inhibitory activity was found to be related to transferrin. No activity was obtained using iron-unsaturated transferrin, whereas iron-saturated transferrin appeared to be potent. The in vivo inhibition of IgE-dependent mediator release from rat mast cells was also obtained using free iron. This effect was observed when iron was injected prior to or simultaneously with mouse IgE in rat skin. Iron and iron-saturated transferrin could play a role in the mechanism of desensitization by modulating the responsiveness of mast cells.
[Clinical aspect of kerato-acanthoma; its development in 20 months].
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[Lupus tuberculosis of bovine origin caused by accidental inoculation in a veterinarian].
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[Enzyme-immunoassay of grass-pollen and mites antibodies in rabbit antisera on magnetic polyacrylamide agarose beads (author's transl)].
Complex antigens were coupled to polyacrylamide agarose beads which had been made magnetic with iron oxide. Those beads were then used in an enzyme-immunoassay for quantitation of specific antibodies to grass-pollen and mites in rabbit antisera. The results obtained by a direct or an inhibition technique proved the specificity of this assay towards homologous antigens. Moreover, cross-reactions between the various species of grass-pollen could be shown. One advantage of this simple method is that it may avoid use of radioactive compounds.
[Experimental trypanosomiasis in rabbits infected by Trypanosoma equiperdum: some aspects of immune response and coagulation disorders (author's transl)].
Some aspects of immune response and coagulation disorders are investigated on rabbits infected by two strains of Trypanosoma (Trypanozoon) equiperdum giving diseases with different clinical expression. The study of antibodies to trypanosomes emphasizes the high immunogenicity of specific antigenic type glycoprotein, antigenicity of which seems to inhibit common antigens expression. Significant increase of anti-fibrinogen antibodies is discussed in relation with the presence of autoantibodies frequently discovered along trypanosomiasis. As IgM they contribute to the classical hypermacroglobulinemia of these diseases. Their casual contribution in the contribution in the casual contribution in the observed disorders is argued. The meaning of fibrinolytic system activation which is shown by FDP significant increase is equally argued: secondary fibrinolysis or Hageman Factor activation mediated by immune complexes.