Optokinetic responses of vestibular nucleus neurons in the rat.
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Biomedical subjects
Publications and source records attributed to J Lannou.
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The postnatal development of the responses of rat central vestibular neurons to horizontal angular acceleration was studied in the time and frequency domain. The resting discharge was very low and irregular during the first postnatal days, increased gradually and became more regular throughout the first month and reached adult values approximately by the end of the first month. The relative distribution of type I and type II units was the same in all age groups. Threshold for frequency increase to angular acceleration and sensitivity of unit responses became lower and higher, respectively, as time elapsed after birth. Adult values were reached approximately by the end of the first month. There was a slight tendency towards shorter time constants and smaller phase lags in one-month-old animals when compared with the younger animals. The results are discussed in conjunction with similar work performed in vestibular afferents and correlated with known morphological and behavioral studies.
The activity of single fibers from the saccular nerve has been recorded in isolated head preparations in the frog (Rana esculenta). Nearly all the fibers present an activation or a depression of their activity during the tilting movement in a given direction. This is considered to correspond to the existence of two anatomical populations of haircells in the saccular macula which differ in their functional polarization. The activity of only some units (about 40%) remained increased or decreased when the head was in a tilted position for 4-5 min. This shows that the sacculus is sensitive to the direction of gravity.
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Direct stimulation of the frog's saccular macula shows that the saccular fibers are sensitive to vibrations between 10(-1) (at least) and 8.10(3) Hz and that their response depends on 1) the frequency of the vibration, 2) the origin of the fiber in the macula.