Search PubMed⌕ Search

Biomedical subjects

J Langley

Publications and source records attributed to J Langley.

82 records · Page 5Linked to original sources
PubMed1979

Malignant melanoma--an overview.

We have presented our experience in light of current practice in the management of malignant melanoma. Central to considerations of adequate management is the question of precise definition of the extent of the disease as determined by histologic evaluation, determination of the depth of penetration and assessment of the extent of spread. Wide surgical excision remains the most important consideration with perfusion therapy, in our view playing a key role in the management of extremity melanoma. Encouraging data for adjuvant immunotherapy continues to unfold. We present here a rational approach to diagnosis and management of malignant melanoma.

Female↗
PubMed1975

Effect of partially purified NSILA on adenylate cyclase, phosphodiesterase and 3',5'-cyclic AMP in fat cells.

Partially purified, non-suppressible, insulin-like material (NSILA-S) was studied with respect to its effect on the levels of 3',5'-cyclic adenosine monophosphate (cAMP) and its mechanism of action in the control of this nucleotide in rat fat cells. NSILA-S prevents the rise of cAMP in fat cells under the influence of isoproterenol with similar kinetics to insulin. A maximal effect is observed at about 70 ng/ml with a biological activity equivalent to 200 muU/ml of insulin. NSILA-S inhibits norepinephrine-stimulated adenylate cyclase activity in fat cell ghosts and partially purified plasma membrane preparations. At 10 mM Mg2+, the inhibition is characterized by an effect of Vmax without change in affinity towards ATP (apparent KM 30 muM). Similarly there is no observed change in affinity towards Mg2+. With respect to inhibition of norepinephrine-stimulated adenylate cyclase, the dose-response curve of NSILA-S is similar to that already found with intact cells. The effect of norepinephrine is inhibited throughout the dose-response range between 5 X 10(-7) and 5 X 10(-4) M. In contrast to previous observations with insulin in ghosts, NSILA-S inhibits the basal adenylate cyclase activity. Cyclic nucleotide phosphodiesterase activity in homogenates as measured at 1.0 muM substrate is increased by 90% after previous incubation of fat cells with NSILA-S. The study suggests that the anti-lipolytic effect of NSILA-S is mediated by a lowering of cAMP through inhibition of the adenylate cyclase and/or stimulation of the phosphodiesterase system.

3',5'-Cyclic-AMP Phosphodiesterases↗
PubMedDate not supplied

Disability in late adolescence. II: Follow-up of perceived limitation.

The disabilities experienced by a large cohort of 18-year-olds have been reported in the previous paper of this series. In this paper, we present the results of a detailed examination of the extent to which the disabilities caused limitation in the everyday activities of this group of young people. The results showed that nearly three-quarters of the members of the sample reported having one or more difficulties in performing activities in their daily lives, though the extent of limitation on their activities was low for most adolescents. Of this group who reported any type of disablement, 23% indicated it imposed very little general limitation on their lives (on a five point scale) and 6% rated it at the highest degree of limitation. Approximately half those with a disability felt the condition was improving, but 28% required an aid or help from another person. From 8% to 11% of those with a disability rated it as serious in relation to aspects of their daily living (education, leisure, social and work) and about half of those with a serious degree of limitation had sought help. The most common disabilities related to behaviour, communication and situations, for example environmental factors. As part of an ongoing study, the results provide a base from which to examine the extent and severity of disability among young people and change in disability as a result of the ageing process.

Activities of Daily Living↗