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Biomedical subjects

J Lange

Publications and source records attributed to J Lange.

274 records · Page 16Linked to original sources

[The gerontopsychiatric team in the specialized department].

People 65 years and older constitute a group with high risk for psychiatric disease, and their numbers are increasing. At the same time familial networks and financial resources are weakening. In order to improve psycho-geriatric therapy, we developed teamwork within our department. In the present work we describe the psycho-geriatric ward and the special functions of team members. It seems to be important that there are enough staff members who are well trained and motivated; it should be guaranteed that members regularly meet in conferences and have regular supervision; work hours should be favorable. Team process is described as consisting of imaging a comprehensive idea of the personality and the problems of the patient; agreeing on a therapeutic proceeding and-as a result-translating into action. Finally, it focuses on the necessity for further development and research.

Aged↗

Bicyclic [b]-heteroannelated pyridazine derivatives. Part 5. Synthesis of some triazolo[4,3-b]pyridazine and pyridazino[6,1-c]triazine derivatives as potential benzodiazepine receptor ligands.

4-Substituted-tetrahydropyridazine-3,6-dione 3-hydrazones [I] reacted with strong carboxylic acids and some acyl chlorides to give the N-acylation products and/or triazolo[4,3-b]pyridazine derivatives. Derivatives of this bicyclic structure were obtained also in reactions of I with triethyl orthoformate and orthoacetate. In the reaction with phosgene, triazolo[4,3-b]pyridazine-3,6-dione, and with oxalyl chloride pyridazino[6,1-c]triazine-3,4,7-trione derivatives were obtained.

Animals↗

Bicyclic [b]-heteroannelated pyridazine derivatives. Part 6. Aromatization of some tetrahydrotriazolo[4,3-b]pyridazine derivatives with potential activity as benzodiazepine receptor ligands.

Aromatization of the pyridazine ring in 8-aryl-7,8-dihydro-3-trifluoromethyltriazolo[4,3-b]pyridazin -6(5H)-ones in the reaction with a phosphorus pentachloride-phosphorus oxychloride mixture yielded the corresponding 6-chloro compounds. Since halogenation at C-7 was accompanied by an instant 7,8-dehydrohalogenation, the reaction with bromine gave the 7,8-dehydro analogs with no change of the carbonyl function at C-6. Benzoylation yielded the O-benzoyl derivative as found by X-ray crystallography. Substitution of chlorine at C-6 for an amine or thioether function was effected in the reactions with hydrazine, amines, and thiophenols. In vitro tests revealed low affinity of the compounds for the benzodiazepine receptor.

Ligands↗