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Biomedical subjects

J Lane

Publications and source records attributed to J Lane.

138 records · Page 8Linked to original sources
PubMedDate not supplied

Severe pulmonary hypertension as a cause of reverse aortic arch flow in the neonate: report of two cases.

We describe two newborn infants with severe pulmonary hypertension and circulatory collapse. In both cases, pulsed and color flow Doppler studies showed systolic and diastolic reversal of flow in the transverse aortic arch to the level of the innominate artery. No associated cardiac or noncardiac anomalies could explain the reverse flow in the aortic arch. Severe pulmonary hypertension and low left ventricular output were thought to be responsible for the Doppler findings. Reversal of the aortic arch flow in the newborn with pulmonary hypertension may be associated with a poor prognosis, and early consideration of extracorporeal membrane oxygenation in such patients may be indicated.

Aorta↗
PubMedDate not supplied

Phosphate depletion syndrome: case report with bone and muscle histology findings and review of the literature.

A 44-yr-old woman with a 16-yr history of heavy antacid ingestion was evaluated for severe weight loss, weakness, bone pain, and multiple fractures. Laboratory investigation revealed severe hypophosphatemia with undetectable phosphate in the urine. Serum parathyroid hormone (PTH), 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D levels were normal. Transiliac bone biopsy revealed evidence of mineralization defect compatible with hypophosphatemic osteomalacia. Bone densitometry documented decreased bone density with a low mineral content. Management included withdrawal of antacids and provision of phosphate-supplemented enteral nutrition, which resulted in prompt weight gain and resolution of the clinical and biochemical abnormalities. The pathogenesis, diagnosis and histological features of hypophosphatemic osteomalacia are discussed.

Adult↗
PubMedDate not supplied

Induced basal normoglycemia and altered platelet aggregation in non-insulin-dependent diabetes.

Non-insulin-dependent diabetic subjects had abnormally raised in vitro platelet aggregation rates to collagen or ristocetin when thought to be "well-controlled" on diet alone but shown to have raised basal plasma glucose levels. Basal normoglycemia, induced with either ultralente insulin or chlorpropamide, was associated with a significant reduction of the enhanced platelet aggregation rates to normal. Some sulfonylurea drugs have been reported to have specific anti-platelet aggregatory properties, but the degree of plasma glucose control is probably more relevant.

Blood Glucose↗
PubMedDate not supplied

Use of ceftazidime-impregnated polymethyl methacrylate beads in the treatment of Pseudomonas osteomyelitis.

Antibiotic-impregnated polymethyl methacrylate beads have been used in other countries to treat osteomyelitis. The drug of choice for this has historically been gentamicin. The authors have chosen ceftazidime to treat iatrogenic Pseudomonas aeruginosa osteomyelitis in rabbit femurs. After implanting the beads, the rabbits were killed at various times in the treatment period. Rabbits were killed at 15 days and later showed no signs of current osteomyelitis, including cultures and histologic examination. Blood antibiotic levels were measured at euthanasia and were minimal for all animals. It appears that ceftazidime may be an effective alternative to gentamicin, especially in treating gentamicin-resistant P. aeruginosa.

Animals↗