Conference stresses crucial role of vaccines.
Explore the source record for details and available documents.
American Nurses' Association↗
Biomedical subjects
J Lambert
Publications and source records attributed to J Lambert.
[Evaluation and validation of a test of psychological distress in a general population in french Quebec].
Psychological distress scales used in epidemiologic surveys usually show high construct validity. The content validation however is less convincing since these scales rest on lists of psychiatric symptoms which are hypothesized as the very content of a psychological distress. This study presents the results of the construct and criterion validation of a new Psychological Distress Manifestations Measure Scale (PDMMS) founded on an initial list of manifestations derived from an original content validation in a general population. Twenty-three items are grouped in four oblique factors with Cronbach's alpha ranging between 0.81 and 0.89. High scores on the scale are correlated with psychoactive drugs consumption, visits to health professionals and self-evaluations of psychological health.
Adolescent↗
Folic acid treatment of hyperhomocysteinemia in peritoneal dialysis patients: no change in endothelial function after long-term therapy.
BACKGROUND: Hyperhomocysteinemia occurs in renal failure and may increase the risk for cardiovascular disease, possibly by damaging the endothelium. Folic acid and betaine are required in two separate homocysteine conversion pathways and may therefore lower plasma homocysteine. OBJECTIVE: To study the therapeutic role of betaine and the effect on endothelial function of long-term homocysteine-lowering therapy with folic acid, in peritoneal dialysis (PD) patients. PATIENTS AND DESIGN: Thirty PD patients were randomized to a 12-week treatment with 5 mg folic acid and 4 g betaine daily, or to 5 mg folic acid alone daily. They were then rerandomized to treatment with 1 or 5 mg folic acid daily for 40 weeks. MEASUREMENTS: At baseline and after 52 weeks, endothelial function was assessed by determination of endothelium-dependent vasodilatation and biochemical markers. RESULTS: Plasma total homocysteine (tHcy) was elevated at baseline: 42.6 (5.8) micromol/L. Only 1 patient (3%) had a normal plasma homocysteine (i.e., < or = 15 micromol/L) before therapy. Normalization of plasma homocysteine occurred in 39% of the patients at 12 weeks. Betaine had no additional homocysteine-lowering effect. Plasma tHcy levels were similar during treatment with 1 or 5 mg folic acid daily. Endothelial function was impaired at baseline and had not improved after 52 weeks of treatment. CONCLUSIONS: Peritoneal dialysis patients have hyperhomocysteinemia, which can be normalized with folic acid alone in about 40% of patients. Betaine does not further lower plasma homocysteine. A maintenance dose of 1 or 5 mg folic acid daily results in equivalent plasma homocysteine levels. Long-term reduction in plasma homocysteine did not result in improvement of endothelial function as assessed by our methods.
Betaine↗
[Elaboration and validation of a tool to measure psychological well-being: WBMMS].
Psychological well-being scales used in epidemiologic surveys usually show high construct validity. The content validation, however, is less convincing since these scales rest on lists of items that reflect the theoretical model of the authors. In this study we present results of the construct and criterion validation of a new Well-Being Manifestations Measure Scale (WBMMS) founded on an initial list of manifestations derived from an original content validation in a general population. It is concluded that national and public health epidemiologic surveys should include both measures of positive and negative mental health.
Adolescent↗