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Biomedical subjects

J Lalau Keraly

Publications and source records attributed to J Lalau Keraly.

5 recordsLinked to original sources
PubMed1986

[Middle-term course of craniopharyngiomas in children as a function of initial therapeutic choice].

Despite numerous studies and publications, the treatment of craniopharyngiomas in children remains controversial. The present series of 33 cases, followed for the last 10 years, is analysed according to therapeutic protocols jointly defined, case by case, from each patient's features and in restricting the extent of surgical excisions. In agreement with other recently published series, two options give superior results: complete excision, when the risk is low; in the other cases, partial excision or rather a simple biopsy or decompression, followed by irradiation. Risks of relapse are thus quite reduced and mortality greatly reduced. The unavoidable consequence of hypopituitarism is easily treated. However, the frequency of psychic and/or neurologic sequellae as well as the risk of post-radiation complications should not be disregarded when selecting treatment.

Adolescent↗
PubMed1985

[Mixed gonadal dysgenesis. Apropos of a series of 21 cases].

Twenty-one cases of mixed gonadal dysgenesis referred at age 1 to 16 years are studied. External genitalia were in most cases of types III-IV, with a small penis and posterior hypospadias, asymmetrical genital folds containing an externalized testis on one side. The internal genitalia varied according to the degree of dysgenesis of the gonads, and included an uterus and/or a vagina in 18 among the 21 cases. A chromosomal mosaicism XO/XY or XX/XY was found in 11 patients, the other 10 having a normal 46 XY caryotype. Pubertal follow-up was obtained in 10 cases, and showed always a male sexual development, without possibility to exactly evaluate the function of the testis. Choosing the sex assignment is relatively easy in newborns or infants with mixed gonadal dysgenesis. It relies more on anatomy (size of corpora cavernosa, feasibility of urethroplasty or vaginoplasty) than on the results of hormonal measurements. The presence of an Y chromosome is not by itself an argument to choose the male sex. In most cases, the choice of the female sex is the easiest and relies on strong clinical arguments, but it leads unavoidably to suppress both the testis and the dysgenetic gonad.

Adolescent↗
PubMed1984

[Dietary intake, circulating levels and excretion of carnitine as a function of age in normal children].

Carnitine metabolism was investigated in 52 normal children aged 1 day to 15 years. Plasma carnitine concentration averaged 83,8 +/- 6,2 (SE) microM, with no age related variation, while both alimentary intake and excretion increased linearly with growth. Carnitine clearance reaches mature levels soon after birth (0.058 +/- 0.007 ml/kg/min). Carnitine intake is significantly higher than excretion only in the first 5 years of life, a fact which suggests a primary role for diet in the supply of carnitine during this period.

Adolescent↗
PubMedDate not supplied

[Pathophysiology of gastroesophageal reflux and esophagitis (author's transl)].

Two new data explain pathophysiology of gastroesophageal reflux and esophagitis: first, the low esophagus pressure is altered in the reflux, second, the biliary salts act a part in the determination of esophagitis. New methods of explorations are proposed: esophageal manometric study, measure of intraluminal pH and soon perhaps radio isotope. That better understanding, those new explorations should allow to choose better than yesterday, therapeutic schemes. But many questions remain without answer.

Esophagitis↗