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Biomedical subjects

J L Wade

Publications and source records attributed to J L Wade.

24 records · Page 2Linked to original sources
PubMed1986

Toxicity, distribution, and elimination of thiol complexes of methylmercury after intracerebral injection.

Intracerebral injection of CH3Hg and CH3Hg complexed with glutathione (GSH), cysteine (cys), cysteinylglycine (cys-gly), and homocysteine (homocys) resulted in differences in toxicity. Criteria based on neurological indices, mortality, and weight loss indicated that the cys-gly complex of CH3Hg was significantly less toxic than CH3Hg or the other complexes. The other complexes of CH3Hg (GSH, homocys, and cys) were also found to be less toxic than CH3Hg. The selenium status of the animal did not seem to significantly influence the toxicity of CH3Hg and the complexes. While CH3Hg complexed to cys-gly was significantly less toxic than CH3Hg alone, there were no differences observed in the CH3Hg half-life values or in the distribution of these compounds in the kidneys, brain, liver, and blood. It was observed, however, that the CH3Hg--cys-gly complex had higher fecal excretion on d 3 and 4 following intracerebral injection.

Analysis of Variance↗
PubMed1984

Neurocrest and colonic tumors: new clinical syndrome. Report of three cases.

This report describes three patients with both multiple intestinal polyps and tumors of neural crest origin. This combination of findings may represent a new clinical syndrome. The embryologic relationships between tumors derived from endoderm and tumors derived from neurocrest are described. An inherent defect in tissue proliferation or repair is postulated to explain the abnormal growth in these two different cell lines.

Adenoma↗
PubMed1984

Operation for diagnosis and treatment of pericardial effusions.

UNLABELLED: An experience with 32 consecutive patients with pericardial effusions is reviewed and presented. Malignant effusions: Twenty patients had underlying malignancy. Five had no symptoms, nine had ambiguous symptoms, and six had pericardial tamponade. Initial treatment in eight was pericardiocentesis, which provided diagnosis and treatment in one but was clinically unsuccessful in seven and caused right ventricular puncture in one. Subxiphoid pericardial window in 19 patients showed malignant involvement in six but documented a nonmalignant effusion in 13. There were no operative complications, and no effusions have recurred with long-term follow-up. Only two patients with true malignant effusions had significant long-term survival as compared with 11 of 13 with benign effusions. Uremic effusions: Six patients with renal failure required intervention, three for hemodynamic compromise and one for possible infection. Diagnostic pericardiocentesis documented a sterile effusion in one patient. Five patients had subxiphoid pericardial window without recurrence of effusion. One patient required reexploration for rectus muscle bleeding. Other effusions: All six patients had hemodynamic compromise. Pericardiocentesis was successful in three of four patients but effected resolution in none. Subxiphoid pericardial window was performed in all. The effusion recurred in a patient with periarteritis nodosa, and a patient with viral myocarditis developed a left ventricular pseudoaneurysm that required operation. CONCLUSIONS: Subxiphoid pericardial window provides definitive diagnosis and treatment for pericardial effusions of all causes with low morbidity rates whereas pericardiocentesis is safe but usually ineffective/unproductive; many effusions in patients with cancer are not related to malignant pericardial involvement and documentation is important for treatment planning.

Adolescent↗
PubMedDate not supplied

Treatment of malignant pheochromocytoma with combination chemotherapy.

Three patients with rapidly progressive, disseminated malignant pheochromocytoma were treated with a combination chemotherapeutic regimen consisting of cyclophosphamide, vincristine, and dacarbazine in repeated 21- to 28-day cycles. All three patients had a marked decrease in blood pressure and an improvement in performance status within the first few cycles of treatment. At a follow-up of 6 to 13 months all patients continue to receive chemotherapy with further regression of tumor in two and stable disease in one. Their blood pressure is normal with minimal or no antiadrenergic therapy. Therapy has been well tolerated; moderate reversible granulocytopenia, neurotoxicity, and one episode of pneumonitis have been the major toxicities encountered. Thus, combination chemotherapy appears to be effective for symptomatic malignant pheochromocytoma.

Adrenal Gland Neoplasms↗