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Biomedical subjects

J L Vercher

Publications and source records attributed to J L Vercher.

45 records · Page 3Linked to original sources
PubMed1988

Cerebellar involvement in the coordination control of the oculo-manual tracking system: effects of cerebellar dentate nucleus lesion.

When the hand of the observer is used as a visual target, oculomotor performance evaluated in terms of tracking accuracy, delay and maximal ocular velocity is higher than when the subject tracks a visual target presented on a screen. The coordination control exerted by the motor system of the arm on the oculomotor system has two sources: the transfer of kinaesthetic information originating in the arm which increases the mutual coupling between the arm and the eyes and information from the arm movement efferent copy which synchronizes the motor activities of both subsystems (Gauthier et al. 1988; Gauthier and Mussa-Ivaldi 1988). We investigated the involvement of the cerebellum in coordination control during a visuo-oculo-manual tracking task. Experiments were conducted on baboons trained to track visual targets with the eyes and/or the hand. The role of the cerebellum was determined by comparing tracking performance defined in terms of delay, accuracy (position or velocity tracking errors) and maximal velocity, before and after lesioning the cerebellar dentate nucleus. Results showed that in the intact animal, ocular tracking was more saccadic when the monkey followed an external target than when it moved the target with its hand. After lesioning, eye-alone tracking of a visual target as well as eye-and-hand-tracking with the hand contralateral to the lesion was little if at all affected. Conversely, ocular tracking of the hand ipsilateral to the lesion side became more saccadic and the correlation between eye and hand movement decreased considerably while the delay between target and eyes increased. In normal animals, the delay between the eyes and the hand was close to zero, and maximal smooth pursuit velocity was around 100 degrees per second with close to unity gain; in eye-alone tracking the delay and maximal smooth pursuit velocity were 200 ms and 50 deg per second, respectively. After lesioning, delay and maximum velocity were respectively around 210 ms and 40 deg per second, that is close to the values measured in eye-alone tracking. Thus, after dentate lesioning, the oculomotor system was unable to use information from the motor system of the arm to enhance its performance. We conclude that the cerebellum is involved in the "coordination control" between the oculomotor and manual motor systems in visuo-oculo-manual tracking tasks.

Animals↗
PubMed1988

Release of acetylcholinesterase from the guinea-pig cerebellum in vivo.

In the cerebellum there is scant evidence for cholinergic transmission but a large amount of acetylcholinesterase. Although it exists most commonly in a membrane-bound form, the release of a soluble form of this enzyme, within the cerebrum, has indicated that it may have a novel non-cholinergic role. In order to understand why the cerebellum is rich in acetylcholinesterase, the first step has been to investigate the possibility of its release in this structure. Following unilateral application of a depolarizing concentration of potassium ions, there was a large, sustained, calcium-dependent increase in release of acetylcholinesterase, specifically in the local cerebellar cortex; a marked enhancement of acetylcholinesterase release also occurred in the contralateral cerebellum, suggesting that the phenomenon reflected polysynaptic neuronal events. Indeed, systemic administration of harmaline, which modifies activity in certain cerebellar afferent pathways, induced a significant increase in acetylcholinesterase release in the cerebellar cortex. Local administration of the cholinomimetic, carbachol, had no effect. It is concluded that acetylcholinesterase is released from cerebellar neurons in association with physiological events, yet unrelated to cholinergic transmission.

Acetylcholinesterase↗
PubMed1984

Origin of eye movements induced by high frequency rotation of the head.

Perception of stability of the visual world and control of ocular fixation and tracking are altered in subjects submitted to high frequency vibration. Studies of the eye movements induced in man by passively rotating the head sinusoidally around a vertical axis show that beyond 8 Hz, the amplitude of the eye movements increases and reaches 2.5 times the amplitude of head movement at 30 hz. The high amplitude eye oscillation may, at least in part, explain the perception of visual world instability and the decrease of visuo-oculomotor system performance in man submitted to high frequency vibration. Two interpretations of this phenomenon have been proposed (9). High amplitude eye movements induced at high frequency may be due to either a non-linearity of the vestibulo-ocular reflex (VOR) or mechanical resonance oscillations of the orbital apparatus. To test these hypotheses, baboons were trained to fixate visual targets. Each animal's head was rigidly attached to a rotating frame through a block of dental cement bolted to the skull. Head rotation was produced by a servo-controlled vibrator. Rotations in the frequency range 1 to 20 Hz were successively applied with the animal in darkness or fixating a stationary target. The results showed that gain curves obtained with baboons are similar to those obtained with man. Paralysis of the muscles of one eye by injection of lidocaine disclosed a behavioral asymmetry of the two eyes at low frequency. The paralysed eye showed no movement below 8 Hz, while the normal eye behaved as in the normal situation. Beyond 8 Hz, the gain of the treated eye increased gradually so that beyond 12 Hz, the two eyes responded.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1984

[Experimental design for the study of adaptive properties of the visuo-manual system in subjects newly provided with optic corrections].

Optical corrections may produce, during the first days of wearing, behavioral and psychophysiological changes such as a sensation of illusory motion of the visual world upon head rotation and errors in the manipulation of objects under visual guidance. After a few days, adaptation takes place, leading to the recovery of adequate sensory-motor performance. We describe an experimental system designed to study the adaptation of the visuo-manual system after exposure to optical corrections. The systems consists of a data tablet/digitizer and a micro computer. The quantification of the adaptation is based on the comparison of the average performance of a subject in a visuo-manual pointing task before and after a practice period consisting of pointing at visual targets through the optical corrections. Preliminary results from tests executed with normal subjects show that the system is perfectly suitable to determine the ability of an individual to adapt to optical corrections. This system can be used to systematically study the adaptation phenomena resulting from the alteration of the normal visuo-manual relationship by optical systems.

Adaptation, Ocular↗
PubMed1983

[Development and training of monocular motor control].

Misalignment of the visual axes of the eyes observed in strabismus may result from sensory, motor, and/or central nervous system disorders. The functional properties of a technique designed to increase, through training, the monocular motor control of normal human subjects was evaluated, the ultimate goal being obviously to apply the technique to cases of minor strabismus. The subject is seated in front of a television screen. A diaphragm extending from the subject's head to the screen divides the picture into two visually separated half fields. A micro-computer was programmed to project two patterns on the screen, made up of vertical green and grey bars (spatial frequency, 3 deg.). Displacement of the two visually superposable half fields could be independently achieved. The subject's task was to fixate, with one eye, the corresponding half field maintained stationary and track, with the other eye, the motion of the second half field. Perfect fusion of the two half fields has to be preserved during movements of the mobile half field over 2 to 6 degrees at a frequency of 0.4 Hz. The results show that after a few training sessions, subjects developed a high gain monocular motor control. This observation suggests that the method may be used as therapy to correct minor strabismus with or without anomalous retinal correspondence, and offers the possibility to study static and dynamic characteristics of Panum's areas and particularly their modifications as a function of training of monocular motor control.

Adolescent↗
PubMedDate not supplied

Egocentric visual target position and velocity coding: role of ocular muscle proprioception.

Limited knowledge is available regarding the processes by which the brain codes the velocity of visual targets with respect to the observer. Two models have been previously proposed to describe the visual target localization mechanism. Both assume that the necessary information is derived from the coding of the position of the eye in the orbit, either through a copy of the muscular activation (out flow model) or through eye muscle proprioception (in flow model). Eye velocity coding might be derived from velocity sensitive ocular muscle proprioceptors or from position coding signals through differentiation. We used techniques based on manual pointing and manual tracking of visual target, combined with passive deviation of one covered eye, to demonstrate that ocular muscle proprioception is involved in (i) eye-in-head position coding, hence in target localization function; (ii) long-term maintenance of ocular alignment (phoria); and (iii) sensing of visual target velocity with respect to the head. These observations support other data now available, describing the processes by which the brain codes position and velocity of visual targets. Such findings might interest engineers in the field of robotics who are facing the problem of providing robots with the ability to sense object position and velocity in order to create an internal model of their working environment.

Humans↗
PubMedDate not supplied

Eye-head movement coordination: vestibulo-ocular reflex suppression with head-fixed target fixation.

To maintain clear vision, the images on the retina must remain reasonably stable. Head movements are generally dealt with successfully by counter-rotation of the eyes induced by the combined actions of the vestibulo-ocular reflex (VOR) and the optokinetic reflex. A problem of importance relates to the value of the so-called intrinsic gain of the VOR (VORG) in man, and how this gain is modulated to provide appropriate eye movements. We have studied these problems in two situations: 1. fixation of a stationary object of the visual space while the head moves; 2. fixation of an object moving with the head. These two situations were compared to a basic condition in which no visual target was allowed in order to induce "pure" VOR. Eye movements were recorded in seated subjects during stationary sinusoidal and transient rotations around the vertical axis. Subjects were in total darkness (DARK condition) and involved in mental arithmetic. Alternatively, they were provided with a small foveal target, either fixed with respect to earth (earth-fixed target: EFT condition), or moving with them (chair-fixed-target: CFT condition). The stationary rotation experiment was used as baseline for the ensuing experiment and yielded control data in agreement with the literature. In all 3 visual conditions, typical responses to transient rotations were rigorously identical during the first 200 ms. They showed, sequentially, a 16-ms delay of the eye behind the head and a rapid increase in eye velocity during 75 to 80 ms, after which the average VORG was 0.9 +/- 0.15. During the following 50 to 100 ms, the gain remained around 0.9 in all three conditions. Beyond 200 ms, the VORG remained around 0.9 in DARK and increased slowly towards 1 or decreased towards zero in the EFT and CFT conditions, respectively. The time-course of the later events suggests that visual tracking mechanisms came into play to reduce retinal slip through smooth pursuit, and position error through saccades. Our data also show that in total darkness VORG is set to 0.9 in man. Lower values reported in the literature essentially reflect predictive properties of the vestibulo-ocular mechanism, particularly evident when the input signal is a sinewave.

Dark Adaptation↗
PubMedDate not supplied

Visual object localization through vestibular and neck inputs. 2: Updating off-mid-sagittal-plane target positions.

The vestibular signal plays a significant role in sensing changes in head orientation during rotations and in determining the magnitude of the rotations, but has only minor contributions in updating the internal representation of object positions with respect to the body after body rotations. The small contribution of the vestibular signal in egocentric object localization was evidenced in experiments in which the subjects reported the remembered position of eccentric earth-fixed targets after passive body rotations. The experiment reported here tested whether motor systems, such as the oculomotor system, make use of vestibular signals to generate accurate goal-directed motor responses toward a target whose position needs to be updated with respect to the body during and after whole-body rotations. The results showed that although subjects can produce saccadic eye movements of about the same magnitude as passive whole-body rotations (as previously reported by a number of researchers), they failed to generate accurate saccades toward the position of an extinguished peripheral visual target after the rotation. Overall, these results combined with those found in the literature suggest different central processes for determining changes in body orientation in complete darkness and for updating a target position with respect to the body during and after body rotations.

Adult↗