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Biomedical subjects

J L Treasure

Publications and source records attributed to J L Treasure.

26 records · Page 2Linked to original sources
PubMed1994

Ways of coping in women with eating disorders.

The aim of this study was to investigate the strategies used for coping with stress in eating disorder patients. Twenty-four anorexia nervosa (AN) patients, 66 bulimia nervosa (BN) patients, and 30 female control subjects completed a revised Ways of Coping Checklist, indicating how they dealt with a self-nominated stressor. The AN and BN patients used proportionately more avoidance than control subjects. The BN patients used proportionately more wishful thinking and sought less social support than control subjects but patients with AN did not differ significantly from either BN or control groups. Patient groups did not differ significantly from control subjects on their use of problem-focused coping or self-blame, although the use of problem-focused coping was significantly lower, and self-blame significantly higher, with psychological problems than with relationship and general problems in all groups. Coping failed to predict severity of eating pathology but, in the patient groups, Beck Depression scores were related positively to avoidant coping (avoidance in BN patients and wishful thinking in AN patients) and inversely to problem-focused coping and seeking social support (although the latter just failed to reach significance in the AN group). It is concluded that a treatment approach that teaches coping strategies, as well as removing the obstacles (cognitive, emotional, or practical) that preclude the use of more effective coping, may be a useful component of treatment.

Adaptation, Psychological↗
PubMed1988

The ultrasonographic features in anorexia nervosa and bulimia nervosa: a simplified method of monitoring hormonal states during weight gain.

Ovarian volume and the diameter of the intra-ovarian follicles correlated with the percentage of premorbid weight in 36 patients with anorexia nervosa who had repeated pelvic ultrasound scans during weight gain. Oestradiol levels increased when the follicles became dominant and were greater than 1 cm in diameter; and uterine growth increased linearly with plasma oestradiol. Pelvic ultrasonography can thus be used as a simple, rapid, bioassay to determine hypothalamic-pituitary-ovarian function in patients with anorexia nervosa and provides a useful guide to the degree of weight restoration required to enable menstrual function to recover. The outcome of anorexia nervosa may be related to the degree to which the biological consequences of starvation which perpetuate the disorder are overcome. The menstrual abnormalities in bulimia nervosa are associated with pelvic ultrasound findings such as small multifollicular ovaries and small uterine areas which also occur in anorexia nervosa and simple weight loss amenorrhoea. This suggests that weight loss or the nutritional disturbance in bulimia nervosa may underlie the menstrual irregularities which commonly occur in this condition.

Anorexia Nervosa↗
PubMed1988

Weight gain and reproductive function: ultrasonographic and endocrine features in anorexia nervosa.

Pelvic ultrasonographic measurements and reproductive hormone levels in 36 patients with anorexia nervosa were followed as they gained weight during inpatient treatment. In 24 patients who were severely malnourished (69% of premorbid weight) the ovaries were small and amorphous and the levels of LH, FSH and oestradiol were very low. Weight gain led to the appearance of multifollicular ovaries when levels of LH and oestradiol remained low but FSH levels had increased resulting in an LH:FSH ratio of less than 1. The emergence of a dominant follicle in 19 patients after weight gain (to 97% of premorbid weight) was accompanied by an increase in uterine area and associated with increased levels of LH and oestradiol and an LH:FSH ratio greater than 2. Among these patients with a dominant follicle at peak weight, 11 menstruated within a month of discharge. The weight at which normal ovarian morphology returned was related to premorbid weight (P less than 0.002) whereas body mass index (BMI) was poorly related. Our findings suggest that pelvic ultrasonography is probably the best indicator of the weight required for full endocrine recovery and offers advantages over sequential hormonal measurements, and is valuable in the management of patients with anorexia nervosa.

Adolescent↗
PubMed1986

Measurement of potassium concentration on-line with an ion-specific electrode during hemodialysis.

Patients requiring hemodialysis for end-stage renal disease are vulnerable to wide fluctuations in plasma potassium concentration [K+]p. Dialysis of K+ can result in rapid and large changes of [K+]p and result in significant morbidity. Since blood is routinely diverted extracorporeally to the dialyzer, the measurement of [K+]p could be made 'on-line' in this circuit with an ion-selective electrode (ISE) with negligible additional risk. Valinomycin/tetraphenylborate embedded in polyvinylchloride (PVC) electrodes of high K:Na selectivity were manufactured in our laboratory. The electrodes were calibrated in vitro and placed in a T diverter tube upstream from the dialyzer. Intermittently small amounts of blood were diverted to flow past the electrode allowing measurement of the electrical potential developed between the ISE half cell and a Ag:AgCl electrode placed 4 mm from the valinomycin membrane which could be read as [K+]p ISE. Blood flowing through the T diverter was then collected in glass tubes for measurement of [K+]p by flame photometry. Forty-six comparative measurements were made for 6 patients who had given informed consent for study. Least squares regression analysis for all observations gave a correlation coefficient of 0.95 and a regression equation of y = 1.1 X -0.39. Only six samples were discrepant by 0.5 mmol/l, and all of these had [K+]p greater than 5.0 mmol/l where the ISE measurements were less precise. Although the correlation of the two techniques was less than perfect, the ISE shows potential utility for monitoring trends of [K+]p instantaneously during hemodialysis.

Electrodes↗
PubMedDate not supplied

Cystic ovaries: a phase of anorexia nervosa.

The ultrasonographic appearance of ovaries and uterus during weight-gain in patients with anorexia nervosa is described. In 11 patients who had sequential scans, ovarian volume on admission was considerably smaller than that of normal women but increased logarithmically with weight-gain. When body mass index (BMI) reached 17 kg/m2, ovaries were shown to contain multiple small cysts in all cases. In 5 patients further weight-gain led to the appearance of a dominant cyst; average BMI was approximately 19 kg/m2 at this stage. The changes in ovarian morphology resembled those of normal pubertal development. These results lend support to the suggestion that hypothalamic-gonadal axis dysfunction in anorexia nervosa is a concomitant of starvation; in the management of infertility, an ultrasonographic appearance of cystic ovaries should alert the clinician to the likelihood of undernutrition as the primary disorder in need of treatment.

Adolescent↗