Biomedical subjects

J L Torres

Publications and source records attributed to J L Torres.

39 records · Page 3Linked to original sources

PubMedDate not supplied

Neoglycopeptide synthesis and purification in multi-gram scale: preparation of O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-N alpha-fluoren-9-yl-methoxycarbonyl-hydroxyproline and its use in the pilot-scale synthesis of the potent analgesic glycopeptide O1.5-beta-D-galactopyranosyl [DMet2, Hyp5]enkephalinamide.

The preparation of a beta-galactosylated hydroxyproline derivative and its use in the multi-gram solid-phase synthesis of the potent analgesic neoglycopeptide O1.5-beta-D-galactopyranosyl [D-Met2, Hyp5]enkephalinamide is described in this paper. The most closely related impurities have been identified, isolated and characterized. Significant aspects of the synthesis and purification affecting yields and purity of both the building block and the target neoglycopeptide are discussed.

Analgesics, Opioid↗

PubMedDate not supplied

MR imaging of shoulder injuries in professional baseball players.

Magnetic resonance (MR) imaging was used to evaluate the shoulders of 10 symptomatic professional baseball players and one asymptomatic player, with surgical correlation in six cases and arthrographic correlation in two cases. Seven small rotator cuff tears measuring 0.5-1 cm were identified on MR images, with arthrographic and surgical confirmation of these findings in two patients and surgical confirmation only in three patients. Cortical irregularity and/or subchondral cyst formation at the posterior aspect of the greater tuberosity near the insertion site of the infraspinatus tendon was found in five of the seven players with rotator cuff tears. Similar findings were noted in the asymptomatic volunteer and in one of the three players without cuff tear, who also had irregular thickening of the posterior capsule. These findings are believed to represent chronic avulsive changes resulting from the deceleration stresses of the follow-through motion.

Adult↗

PubMedDate not supplied

[Permanent endovascular occlusion of the middle cerebral artery in Wistar rats: a description of surgical approach through the internal carotid artery].

INTRODUCTION: The importance of cerebral ischemia in clinical practice has driven the development of diverse experimental models of its different forms and different methods of producing it have been described. Here we report our experience with the use of the internal carotid artery (ICA) as an access route for the permanent endoluminal occlusion of the middle cerebral artery (MCA) in Wistar rats, and a detailed description of the procedure. AIMS: Our aim at the at the Universidad de Cuenca Research Institute was to establish a standard technique for the constant and repeatable production of a focal cerebral infarct in the MCA territory in Wistar rats. MATERIALS AND METHODS: Using a cervical approach, the ICA was dissected in 20 Wistar rats and, by means of an arteriotomy, a 25 mm long nylon 3-0 or 4-0 filament was introduced until the MCA was obstructed. The infracted area was delimited with 2,3,5-triphenyltetrazolium chloride and its volume was calculated using computer software. RESULTS: Positive results were obtained in 10 cases, the mean volume of the infarct was 488.84 mm3, and the standard error was found to be 63.91 mm3. Subcortical infarcts occurred on three occasions. Two cases presented subarachnoid haemorrhage and two others showed parenchymatous haemorrhages; there were three deaths. CONCLUSIONS: The use of the ICA as an entry point is an effective alternative for the endovascular production of focal cerebral ischemia and the use of a nylon 4-0 filament was more efficient than using a calibre 3-0 filament.

Animals↗