Unconventional arthritis therapies.
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Aged↗
Biomedical subjects
J L Templeton
Publications and source records attributed to J L Templeton.
Is persistent opacification of the gall bladder on cholecystography an indication for cholecystectomy?
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Adult↗
Toxicity of alpha-phenyl-gamma-butyrolactone, a metabolite of glutethimide in human urine.
A novel metabolite, alpha-phenyl-gamma-butyrolactone, isolated from the urine of a glutethimide overdose victim, was synthesized and tested for biological activity in mice. Interperitoneal injections of this lactone caused severe toxicity at moderate dose levels. These results point to another metabolite of glutethimide contributing toxicity to patients severely intoxicated by the parent drug. An improved synthesis as well as complete spectral data of this lactone are also presented.
4-Butyrolactone↗
Identification of a methylated catechol metabolite of glutethimide (Doriden) in human urine.
A new metabolite of glutethimide has been isolated and identified as a methylated catechol. Gas chromatographic parameters as well as mass spectral data are presented which clearly reveal this metabolite to be present in enzymatically hydrolyzed urine of patients severely intoxicated by the parent drug.
Catechols↗
Synthesis and characterization of a catechol metabolite of glutethimide (Doriden) in human urine.
A metabolite of glutethimide, 2-ethyl-2-(3,4-dihydroxyphenyl)-glutarimide, previously identified in enzymatically hydrolyzed human urine of overdosed victims was prepared synthetically and its chemical and spectral data compared to the proposed material. Results of these comparisons confirm the presence of a catechol metabolite of glutethimide in the urine of patients severely intoxicated by the parent drug.
Catechols↗
Synthesis and characterization of alpha-phenyl-gamma-butyrolactone, a metabolite of glutethimide, phenobarbital and primidone, in human urine.
A novel metabolite, alpha-phenyl-gamma-butyfolactone has been isolated in urine samples of patients severely intoxicated by either glutethimide, phenobarbital, or primidone. This lactone was prepared synthetically and its spectral data and chromatographic properties were compared to those data obtained from the urine samples of drug overdosed victims. The results of these comparisons confirm the presence of this lactone in human urine following the ingestion of large amounts of the parent drug.
Glutethimide↗
Phenolic metabolite, 2-ethyl-2(4-hydroxphenyl)-glutarimide in human urine following chronic ingestion of glutethimide (Doriden).
Urine samples from comatose patients, identified as having taken large amounts of the drug, glutethimide, were analyzed using gas chromatography, mass spectrometry, thin layer chromatography, and nuclear magnetic resonance spectrometry in order to identify metabolites of the parent drug. The phenolic compound 2-ethyl-2-(4-hydroxphenyl)-glutarimide was fully characterized as a new metabolite in human urine. Also 2-ethyl-2-(3-methoxy-4hydroxyphenyl)-glutarimide was proposed as a new metabolite of the parent drug. Other polar metabolites of the parent drug were also detected and partially characterized.
Chromatography, Gas↗
Definitive characterization of the para-hydroxyphenyl metabolite of glutethimide in human urine.
The compound, 2-ethyl-2-(4-hydroxyphenyl)-glutarimide was prepared synthetically. Spectral data is presented which identifies this compound to be a metabolite of glutethimide isolated from enzymatically hydrolyzed human urine, following an overdose of the parent drug. New data supporting the structure of a minor metabolite, 2-ethyl-2-(3-methoxy-4-hydroxy)-glutarimide, is considered. Finally, gas chromatographic techniques have been perfected and are presented which yield complete purification of new metabolites of glutethimide.
Chromatography, Gas↗
Definitive GLC method of identifying cocaine.
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Aniline Compounds↗
Capillary gas chromatographic determination of terbutryn and its degradation products in sorghum grain and confirmation of the compounds by mass spectrometry.
An analytical method with a limit of detection 0.05 mg kg-1 is described for the determination of the herbicide terbutryn and its three degradation products, GS-26575, GS-11355 and GS-26831 in sorghum grains using fused silica capillary gas chromatography. Electron impact and methane chemical ionization mass spectra are reported to confirm the characterization of the compounds. No residues of these chemicals were found in sorghum harvested 14 weeks following terbutryn treatment at 0-4.5 kg ha-1.
Chromatography, Gas↗
Gas chromatographic and mass spectrometric determination of ametryn and its N-dealkylated products.
Gas chromatographic and mass spectrometric properties of ametryn and its N-dealkylated products were studied to establish the potential use in a recently reported method describing the residue analyses of these compounds by gas chromatography with N-P detection. Electron impact mass spectra show base peaks at the molecular ion (M+), and methane chemical ionization mass spectra give base peaks at (M + 1) ion for all the compounds studied. Characteristic mass spectral fragmentations of ametryn, GS-11354, GS-11355, and GS-26831 are presented. Combined gas chromatography-mass spectrometry rather than gas chromatography alone provides unambiguous residue characterization. The technique also allows quantitation of ametryn and its N-dealkylated products that cochromatograph with interfering materials present in a complex substrate.
Chromatography, Gas↗