J L Shupe — Page 4 | Search PubMed

PubMedDate not supplied

Inheritance of limber legs in Jersey cattle.

Pedigree information from 105 cases of limber leg Jersey calves indicate that this semilethal abnormality is inherited as a simple autosomal recessive. The increased incidence of this abnormality in recent years suggests a rise in the gene frequency, probably due to the popularity and widespread use of a carrier bull Favorite Commando, his daughter Marlu Milady, and many of their descendants. Steps to control this abnormality have been taken by the American Jersey Cattle Club.

Animals↗

PubMedDate not supplied

Hereditary multiple exostosis. A comparative human-equine-epidemiologic study.

Hereditary multiple exostosis (HME), a bone tumor first described by Virchow, has been studied over a period of 15 years on a comparative basis. The horse, an excellent biomedical model for this physically deforming multiple bone tumor in man, has been utilized in this study. The etiology, hereditary pattern, potential for malignancy and other aspects of this strange affliction need additional clarification. This in-depth study of 261 individuals from 144 families was compared with that of 55 horses bearing the HME trait, selectively bred and studied over the same period. Important information has been collected and evaluated about this condition that is suspect of being frequently missed diagnostically, with a higher incidence in humans that recognized. Continuing development studies of offspring of the original study participants; sarcomatous transformation monitoring; and recently developed genetic techniques should add to our understanding of this puzzling hereditary condition.

Abnormalities, Multiple↗