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Biomedical subjects

J L Schelling

Publications and source records attributed to J L Schelling.

At least 55 records · Page 3Linked to original sources
PubMed1976

Effect of paracetamol, mephenoxalone and their combination on pain following bone surgery.

Sixty patients suffering moderate postoperative pain after bone surgery were divided randomly into 3 treatment groups on the day following operation. Under double blind conditions they received either 400 mg mephenoxalone, a weak sedative, or 900 mg paracetamol, or the same doses of these drugs simultaneously, three times daily for three days. Pain scores determined by a surgeon 1, 2, 3, and 6 hours after administration of the first dose of the drug indicated that paracetamol and paracetamol + mephenoxalone had similar analgesic effects and were more effective than mephenoxalone alone. However, during repeated administration over 3 days, the mean effect of the drug combination was slightly better than that of paracetamol or mephenoxalone alone. The drug combination did not induce more sedation or gastrointestinal side effects than either drug alone.

Acetaminophen↗
PubMed1976

[Urinary mercury excretion in professional users of an antiseptic soap containing 0,04% phenylmercury borate].

Concentrations of mercury and of creatinine were measured under blind conditions in 84 samples of urine from 48 regularly using a liquid soap containing 0.04% phenylmercuric borate plus 3% hexachlorophene for hand disinfection ("users"), and in 138 urine samples of 80 subjects disinfecting their hands with a soap containing only hexachlorophene ("controls"). The concentration of mercury in the urine of users was 27+/-3 mug/1 (mean +/- SE), and in controls 8+/-1 mug/1; calculated total 24 h urinary mercury excretions were 27+/-2 mug/24 h users and 9+/-1 mug/24 h in controls. Women excreted slightly more mercury than men both in the user group and the control group. In both controls and users from whom a second urine sample was obtained after a 2-week interval the concentration of mercury was consistently lower in the second sample. No correlation was found between urinary excretion of mercury and frequency of handwashings or reported intake of mercury-containing food. No difference was found in the numbers of different types of urinary cells or urine pH as between users and controls. It is concluded 1) that regular hand disinfection with a liquid soap containing 0.04% phenylmercuric borate enhanced urinary excretion of mercury indicating an increase in total daily absorption of 30-100 mug Hg/24 h, 2) that the absorption of mercury from the phenylmercuric borate-containing soap occurred partly by transfer from the hands to the oral cavity, 3) that, though nontoxic in themselves, the additional amounts of mercury absorbed through the use of mercury contained in skin disinfectants are potentially dangerous due to as yet unknown interactions with other toxic or pathogenic factors.

Borates↗
PubMed1976

[The effect of flavonoid compounds (+)-cyanidanol-3 in acute viral hepatitis].

A double blind study was carried out with 14 pairs of patients suffering from acute virus hepatitis in order to determine the action of (+)-cyanidol-3 (2 g daily, administered orally). Among these few patients no significant differences were observed between the two groups. This also holds true for the liver function test with the exception of total serum bilirubin. In the treated patients hyperbilirubinemia decreased significantly faster than in the untreated group (p smaller than 0.05). The values registered with a daily dosis of 1 g (+)-cyanidol-3 did not differ from those recorded in the groups of untreated patients.

Alanine Transaminase↗
PubMed1975

[Factors that intervene in adverse drug reactions].

Drug prescriptions and adverse reactions occurring during 2 periods of 3 months in a department of medicine were analyzed by computer programs. Among 148 reactions suspected, 130 were considered definite or probable by one physician (1.6 reaction per 100 drug prescriptions). The patients who suffered from an adverse reaction were older, were hospitalized for a longer period of time and received more drugs than the others. The data were submitted to two physicians who were asked to determine the degree of probability of each reaction independently. There were many discrepancies between physicians' judgements (52% of the reactions) if one of them had a brief summary of the case history and the other had all the data available. The discrepancies were far fewer (18.1%) if both physicians had all the data available, and were due to the drug(s) suspected (8.8%) or to the influence of the disease (9.3%).

Age Factors↗
PubMed1975

[Plasma concentration of phenytoin in epileptics--importance for the clinician].

Plasma concentrations of diphenylhydantoin were determined by the method of Wallace (double extraction, spectrophotometry) in 150 samples taken from 121 epileptic patients. They correlated well with those determined by gas chromatography, were not dose-dependent and were often below 10 mul/ml. They were above 20 mul/ml in 6 patients with CNS intoxication. These determinations were also useful for detecting patients who did not take the drug as prescribed (14 suspected cases, 4 confirmed). However, blood levels did not seem to offer an accurate index of the effectiveness of diphenylhydantoin.

Adult↗
PubMed1975

[Urinary concentration and antibacterial effect of short and long acting tetracycyline].

Forty-one hospitalized patients, of whom the majority had asymptomatic bacteriuria, were randomly divided into 4 treatment groups. They were given either tetracycline HCl 1 g, or tetracycline HCl + terpenes 100 mg, or minocycline 200 mg, or cotrimoxazole (sulfamethoxazole 1.6 g + trimethoprim 320 mg), daily for one week. A large number of bacteria were resistant to tetracyclines. The urine was sterilized in 14 out of 24 patients receiving tetracyclines and in all of the 17 patients receiving cotrimoxazole. The mean urinary concentration of tetracycline was 20 times higher than that of minocycline. The 24-h urinary excretion of tetracyclines was slightly higher in patients receiving the combination of terpenes and tetracycline, but these differences in urinary excretion did not appear to have any influence on the antibacterial effect of tetracyclines.

Adult↗
PubMed1975

Effect of foodstuffs on the absorption of zinc sulfate.

Single doses of zinc sulfate were given to healthy young volunteers, either in the fasting state or with various types of meals. Dairy products (milk and cheese) and brown bread decreased zinc absorption, as indicated by a significant drop in peak serum zinc levels. Zinc absorption was decreased when zinc was given in the fasting state with the same amounts of purified phosphate or phytate as those found in foods above. Experiments in vitro have shown that zinc is precipitated by phosphate and phytate at pH values close to that of the intestinal lumen. Coffee also seems to inhibit zinc absorption.

Adult↗