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Biomedical subjects

J L Robertson

Publications and source records attributed to J L Robertson.

At least 55 records · Page 3Linked to original sources
PubMed1986

Long-term renal responses to high dietary protein in dogs with 75% nephrectomy.

It has been proposed that ingestion of large amounts of dietary protein leads to sustained renal hyperperfusion and progressive glomerulosclerosis in rats. This hypothesis was tested in dogs, with 75% reduction in renal mass, maintained for 4 years on either 56, 27, or 19% dietary protein. Twelve of 21 dogs survived 4 years, and death due to renal failure was not correlated to diet. Dogs fed 56 and 27% protein had increased GFR and CPAH before and after reduction of renal mass compared to the 19% group. A pattern of deterioration of renal function, including proteinuria, was not found in any diet group. Nine of 11 dogs, fed 56, 27, or 19% protein had minimal glomerular lesions, including mesangial proliferation, GBM irregularities, adhesions, and sclerosis. Two other dogs, fed 56% protein, had more severe glomerular lesions. No significant ultrastructural differences were found in glomeruli among the three diet groups. These results do not support the hypothesis that high protein feeding had a significant adverse effect on either renal function of morphology in dogs with 75% nephrectomy.

Animals↗
PubMed1986

Spontaneous renal disease in dogs.

Renal disease is common in dogs. The incidence of significant renal disease increases with age. Many disease processes are subtle and subacute, and so many are not detected until they result in chronic renal failure. The causes of many renal diseases are not known but one must suspect immune-mediated damage in some.

Aging↗
PubMed1986

Experimentally induced malignant hypertension in beagle dogs.

The pathology of malignant hypertension in dogs induced either purposely or inadvertently by the Goldblatt procedure has not been previously reported. Malignant hypertension was experimentally produced in beagle dogs by a modified Goldblatt procedure; in a single surgical procedure, one kidney was removed and the blood flow to the remaining kidney was reduced by 50%. A sudden onset of severe clinical signs developed within one to three weeks after surgery. The dogs were markedly depressed or in shock, were vomiting, and had either bloody feces or bloody diarrhea. Hematologic changes compatible with a diagnosis of microangiopathic hemolytic anemia consisted of hemolysis, thrombocytopenia, and the presence of burr cells and schistocytes. Some dogs had neutrophilia and slight to moderate increases in blood urea nitrogen and creatinine. At necropsy, there were gross hemorrhages in the heart, brain, urinary bladder, and gastrointestinal tract. Histologic findings consisted of multifocal parenchymal hemorrhage, fibrinoid necrosis of arterioles, medial smooth muscle hyperplasia, adventitial fibroplasia and mononuclear cell infiltrates, and microthrombi. The vascular clamp most likely protected the kidney from the systemic hypertension since the remaining kidney was largely not remarkable by light or electron microscopy. The dog appears to be a good model to study the pathology of malignant hypertension and microangiopathic hemolytic anemia.

Anemia, Hemolytic↗
PubMed1984

Toxic hepatopathy in neonatal foals.

Six foals of three different breeds, born to healthy mares, appeared normal at birth, and died at two to five days of age with icterus, ataxia, head pressing, and terminal hepatic coma. Their livers were less than one-half normal weight. Most of the liver was dark red-brown and slightly rubbery. Histologically, these areas were characterized by severe bile ductule proliferation, mild portal tract fibrosis, and massive hepatocellular necrosis and lobular collapse. A small proportion of the liver, usually on the peripheral part of the lobes, was grossly light brown and slightly raised. Histologically, these areas had mild to severe bile stasis in canaliculi. In the thin marginal zone between the severely affected and mildly affected liver, there was mild bile ductule proliferation and periportal fatty change and necrosis. Alzheimer's type II cells, characteristic of hepatoencephalopathy, were numerous in the brains of all foals. Within two hours after birth, all the foals had been given an oral proprietary nutritional paste, the ingredients of which included a viable Aspergillus sp and an iron compound. Similar lesions were produced in an experimental foal.

Animals↗
PubMed1984

Pathologic findings in the stomachs of rats treated with the H2-receptor antagonist tiotidine.

The gross and histopathologic findings seen in the stomach of rats treated with an H2-antagonist, tiotidine, will be presented. The data presented is from two studies, a six month oral (gavage) and dietary study in male rats, and a 12 month oral chronic toxicity study combined with a 24 month oncogenicity feeding study in rats. Significant findings in the stomach included fundic glandular dilatation, parietal cell atrophy, metaplastic fundic cells, fundic nuclear clusters, and dysplasia/carcinoma lesions. The chronology of the borderline type dysplasia/carcinoma lesions starting from the very early to the more advanced infiltrating carcinomas will be shown. A total of 17 rats with lesions of the dysplasia/carcinoma complex out of 828 treated rats from the two studies were present. No similar type lesions were seen in any of the 432 control rats examined. The importance of the diagnostic methods used in the examination of the stomach is stressed.

Animals↗
PubMed1983

The incidence and significance of rub marks on the stem of removed total hip replacements.

This article presents data on the incidence of rub marks (burnishing) on the stems of 180 removed total hip replacement femoral components most of which were McKees and Stanmores. The incidence varied with the reason for removal. It was low for assorted removals excluding fractured stem removals, higher for "loose stem" removals, and highest for fractured stem removals. For "loose stem" removals, it appeared to increase with implantation time. For fractured stem removals it appeared to increase with the time elapsed between fracture and removal. On not-fractured removals, rub marks appeared to indicate that the component had been loose, but on fractured stem removals they appeared to indicate only that the component had been loose after fracture.

Equipment Failure↗
PubMed1982

Spontaneous cardiac tumors in eight rats.

Spontaneous cardiac neoplasms were diagnosed in one Sprague-Dawley and seven Fischer 344 rats ranging in age from eight months to two years. All eight neoplasms were diagnosed as neurilemmomas. One neoplasm was composed of dense Antoni type A tissue with Verocay body formation, while seven others were composed principally of loose Antoni type B tissue. No specific site predilection was found.

Animals↗
PubMed1979

Augmentation mammoplasty - a hazardous procedure.

A few of the early and late complications of augmentation mammoplasty are described. Although it is classified as a simple technical procedure, the long-term hazards should be taken into consideration before operating on a patient.

Breast↗
PubMed1978

The mismanagement of benign breast disease. A report of 3 cases.

Three cases are presented of complications after bilateral subcutaneous mastectomy with immediate prosthetic replacement, performed for benign breast disease in women who ranged in age from 24 to 32 years, by surgeons outside the field of plastic surgery. This article is submitted as a plea to curb a rapidly increasing tendency by general surgeons to perform a basically mutilating operation on young women with benign breast disease.

Adenofibroma↗