A patient with neonatal glycine encephalopathy who had severe neurologic retardation, spasticity, and seizures died at 17 years of age. Glycine concentration was markedly elevated in brain tissue, especially in the cerebellum. Neuropathologic study revealed spongy myelinopathy throughout the central nervous system and calcium oxalate crystals in the cerebellum, which are probably derived from degradation of glycine. Myelinopathy appeared to be static compared to neonatal patients. The neurologic manifestations of neonatal glycine encephalopathy are probably due to neurotransmitter abnormalities, not to myelin damage.

Adolescent↗

PubMedDate not supplied

Computed tomography in acquired absence of thoracic pedicle.

A patient with an acquired absence of a thoracic pedicle is presented, and the contribution of CT examination is demonstrated. A brief anatomical and radiographic review of congenital and acquired absence of pedicles is provided.

Adult↗

PubMedDate not supplied

Acyclovir crystalluria.

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Acyclovir↗

PubMedDate not supplied

Ludwig angina: an uncommon and potentially lethal neck infection.

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Adult↗