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Biomedical subjects

J L Paterson

Publications and source records attributed to J L Paterson.

25 records · Page 2Linked to original sources
PubMed1982

Effect of phentolamine on the metabolic response to gynaecological surgery.

The effect of the infusion of phentolamine 0.5 mg min-1 on the metabolic response to gynaecological surgery was investigated. In comparison with the control group of patients, phentolamine was associated with a significant increase in plasma insulin concentration after 30 and 60 min of surgery. The glycaemic response to surgery was decreased by alpha-adrenergic blockade, but this was only significant after 120 min of surgery. The hypotension produced by the administration of phentolamine was well tolerated.

Adult↗
PubMed1981

Effect of high-dose fentanyl anaesthesia on the metabolic and endocrine response to cardiac surgery.

The effect of high-dose fentanyl anaesthesia (75 micrograms kg-1) on the metabolic and endocrine responses to cardiac surgery was compared with results obtained in similar patients who had received incremental doses of papaveretum. High-dose fentanyl anaesthesia prevented the increases in blood glucose, plasma cortisol and plasma growth hormone concentrations found before cardiopulmonary bypass, but during cardiopulmonary bypass was only effective in decreasing the hyperglycaemia. The continued administration of fentanyl following operation failed to suppress the hormonal and metabolic changes so that the total urinary excretion during the first 5 days after surgery was similar in both groups of patients. High-dose fentanyl anaesthesia was associated with only transient metabolic benefits confined to the period during operation.

Anesthesia, Intravenous↗
PubMed1981

Fentanyl and the metabolic response to gastric surgery.

The effect of the supplementation of nitrous oxide-oxygen anaesthesia with either 50 micrograms fentanyl/kg body weight or 0.5-1.0% halothane on the metabolic and hormonal response to gastric surgery was investigated in 16 patients. Those patients who received fentanyl showed a significant decrease (p less than 0.05) in the hyperglycemic response to surgery after 30 and 90 minutes and a significant decrease (p less than 0.05) in the plasma cortisol response after 30 minutes. Profound respiratory depression occurred at the end of surgery in all patients who were given fentanyl. This required the intravenous administration of naloxone and careful supervision in the early postoperative period. It is concluded that the transient metabolic and endocrine benefits produced by fentanyl do not compensate for the severe respiratory problems postoperatively and thus 'high-dose fentanyl' cannot be recommended for upper abdominal surgery.

Alanine↗
PubMed1980

Beta-adrenergic blockade and the metabolic response to surgery.

The effect of the administration of propranolol 0.15 mg per kg body weight i.v. on the metabolic response to pelvic surgery was compared with results in similar patients who had not received propranolol. The only significant difference between the two groups was a lower plasma insulin concentration in the beta-blockade patients after 60 and 90 min of surgery. The glycaemic response to surgery was unimpaired in the propranolol-treated patients and there were no adverse haemodynamic effects. We conclude that beta-adrenergic blockage is unlikely to have deleterious metabolic effects on healthy patients.

Adult↗