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J L Parrot

Publications and source records attributed to J L Parrot.

68 records · Page 4Linked to original sources
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[Limb vasodilation provoked by stimulation of the carotid sinus. Importance of histaminergy in the dog].

The vasodilator reflex induced by baroreceptor stimulation was studied on the hindlimbs of the dog. The reflex was induced by norepinephrine (1 microgram/kg) either by intravenous injection or by direct injection into the carotid sinus. In other experiences, the baroreceptor stimulation was obtained by distension of the sinus by rapid injection of 100 ml of physiological serum. The vascular response was studied by recording the hindlimbs blood flow. One of the limbs was previously pretreated by mepyramine and cimetidine (blockage of histaminergic H1 and H2 receptors). During the first minute after the baroreceptor stimulation, blood samples were collected from the venous blood of hindlimbs for histamine assay (fluorometric assay). Our results show: a much lower vasodilation on the limb pretreated by histamine antagonist, a significant increase during the reflex vasodilation of histamine blood levels measured in the efferent blood of hindlimbs. These results, obtained in experimental conditions as physiological as possible (blood perfusion of the limbs with "natural" hemodynamic parameters) permit to conclude that the vasodilation induced by baroreceptor reflex is at least partially histaminergic in the dog.

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[Study of histamine in asthma].

Histamine is generally considered as the principal chemical mediator in experimental allergy of type I and anaphylaxis. However, its part in human bronchial asthma remains discussed, because neither the dosage of histamine in blood, nor the use of antihistaminics have furnished any real evidence. This study is dealing with two elements: the importance of local bronchopulmonary phenomena, and the associated mediators also liberated in asthma, such as SRSA. ECFA, kinines, prostaglandins and disorders of balance between, on one hand, alpha and beta-actions of the catecholamines, and on the other hand, between the two main types of cyclic nucleotides. These considerations should allow a better approach of the asthma etiopathology and perhaps an improvement of its treatment.

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