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Biomedical subjects

J L Michaud

Publications and source records attributed to J L Michaud.

101 records · Page 6Linked to original sources

[Primary lymphosarcoma of the lung secreting immunoglobulin (author's transl)].

A case of primary lymphosarcoma of the lung with monoclonal seric dysglobulinemia of IgM type is reported in a 48-year-old man. This bilateral tumour consisted of lymphocytes with some plasmacytoïd and plasma-cells. There was no bone, liver or lymph node involvement. A 3-year follow-up shows clinical remission with continuous chlorambucil therapy. The interest of the observation lies in the rarity of secretory lymphosarcoma of the lung: only five cases have been reported. Nosologic and diagnostic problems of lymphocyte and plasma cell proliferations in the lung are discussed. The difficulty to differentiate diffuse hemopathy from localized lymphoma and tumour from pseudo-tumour is emphasized.

Humans↗

[Successful medical treatment of post-traumatic tracheo-oesophageal fistulae (author's transl)].

Tracheo-oesophageal fistulae secondary to closed traumatic lesions of the thorax are rarely encountered, and only 38 cases have been reported in the published literature. The causal accident is usually perforation due to steering wheel projection or a crushing injury in a young subject (77% less than 30 years old) with a supple thorax, and parietal lesions are rarely observed. The initial lesion is rupture of the trachea with oesophageal confusion, usually above the level of the carina. The only diagnostic clinical sign is cough on swallowing, and diagnosis suspected on bronchoscopy is confirmed by radiological examination with a contrast medium. Urgent surgical treatment is necessary to repair the tracheal lesion. Secondary disunion may be observed (8--34). The particular characteristic of the cases presently reported was the secondary formation of a fistula after tracheal repair. Direct enteral feeding led to closure of the communication in 6 weeks.

Adult↗

[Multiple and recurrent cardiac myxomas. Is it a familial disease?].

From 1964 to 1992, 56 patients with cardiac myxoma have been operated on. Sixty seven operations have been made during which 85 myxomas have been excised. Five patients had been reoperated from recurrent myxoma: 4 patients 2 times, 1 patient one time. In this population we observe 7 cases of multiple myxomas implanted 7 times in many cavities. The study of this series displays a lot of risk factors: implantation outside the left atrium, multiple myxomas in one or several cavities, true recurrence of myxoma, young age of the patient, associated lesions as part of the Carney's complex. In this series, 13 patients, representing 5 families, have one or more of these risk factors. in two of them, a familial character has been demonstrated. Analysis of these special kinds of cardiac myxomas displays very closed analogy between familial myxomas and high risk group. These findings suggest that recurrent and/or multiple and/or familial myxoma represent the same entity.

Adult↗