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Biomedical subjects

J L Medina

Publications and source records attributed to J L Medina.

At least 19 recordsLinked to original sources
PubMed1992

Nicotine stimulates adrenergic terminals and inhibits contractions of mouse uterine horns.

1. Nicotine (1-100 microM) stimulated both basal and electrically evoked release of 3H-norepinephrine and also caused a transient inhibition of contractions in an in vitro preparation of mouse uterine horns. 2. The inhibitory effect of nicotine on electrically evoked contractions was potentiated by aminophylline (89 micrograms/ml), and overcome by both propranolol (1 microM) and by omitting magnesium from the physiological solution. Acetylcholine (10 microM), in the presence of atropine (10 microM) was able to reproduce the inhibitory effect of nicotine. 3. These pharmacological findings suggest that the inhibitory action of nicotine on electrically evoked contractions in mouse uterus could be indirect, i.e. mediated through the action of this compound on presynaptic nicotine receptors located on adrenergic terminals.

Acetylcholine↗
PubMed1992

Organic headaches mimicking chronic paroxysmal hemicrania.

The article describes two women who had headaches that mimicked chronic paroxysmal hemicrania (CPH). The first patient had a collagen vascular disorder; and the second one, a large malignant tumor in the right frontal lobe. The similarity of the headaches of the first patient to CPH included an absolute response to indomethacin. The existence of these cases may lead to a better understanding of the pathophysiology of CPH. At the same time, their existence also calls for caution in the diagnosis of CPH.

Adult↗
PubMed1992

Efficacy of an individualized outpatient program in the treatment of chronic post-traumatic headache.

Twenty patients disabled for work because of chronic post-traumatic headaches were treated: 13 men, and seven women. Their ages ranged between 26 and 69 years (mean = 40.3). Their accidents occurred three months to eight years prior to the initial visit (mean = 1.5 yrs). Thirteen patients had concurrent spinal injuries. They were assigned to an individualized program with emphasis on doctor-patient relationship. All patients received medications, biofeedback, and educational sessions. Thirteen patients with concurrent spinal injuries received additionally therapeutic exercises and transcutaneous nerve stimulation. Five patients needed neuromuscular re-education, and three, stress management. All sessions were individualized. Patients attended the Center one to three times a week for three to 12 weeks (average = 9 weeks). The number of treatment days ranged from six to 37 (average = 18.8 days). The average cost of the program for patients with headache alone was $3849.00; and for those with additional spinal injuries, $7030.00. All patients improved: markedly, 14; moderately, four; and slightly, two patients. The improvement occurred within seven to 150 days (average = 48.7 days). Seventeen out of the 20 patients, (85%) returned to work within 21-224 days (average = 111 days). An individualized outpatient program is very successful in the treatment of post-traumatic headache.

Adult↗
PubMed1989

Headaches.

Explore the source record for details and available documents.

Headache↗
PubMed1987

Pediatric chest trauma.

Blunt and penetrating chest trauma in children results from many causes but the major cause is motor vehicle accidents. The trauma induces a variety of injuries to the bony thorax, the pulmonary parenchyma, and mediastinal structures. In recent years, a disturbing increase in iatrogenic chest trauma has occurred in patients, particularly small infants, receiving intensive hospital care. Radiologic evaluation plays an important role in documenting and diagnosing these traumatic and iatrogenic injuries. The various radiologic manifestations of these injuries are described and discussed.

Child↗
PubMed1977

The clinical link between migraine and cluster headaches.

We describe seven patients with vascular headaches. Five of them had cluster headaches, which were preceded by migrainous scotamata (two patients), weakness contralateral to the pain (one), accompanied by ipsilateral photopsias (one), or by contralateral paresthesias (one). The other two patients had "clusters" of daily common migraine headaches separated by long free intervals. The symptoms of these patients suggest a common root for cluster and migraine headaches.

Adult↗
PubMed1977

Syndrome of agitated delirium and visual impairment: a manifestation of medial temporo-occipital infarction.

Three patients presented with sudden visual impairment followed by agitated delirium one to three days later. Examination revealed marked agitation, dementia, and loss of vision. Computerised axial tomography demonstrated temporo-occipital infarctions. All recovered from the agitated state in four days to two months, but their visual impairment and dementia persisted one to four years later.

Adult↗
PubMed1976

Localized myokymia caused by peripheral nerve injury.

One year after a gunshot wound in the popliteal fossa, a 30-year-old man began to experience cramps and myokymia in the left gastrocnemius muscle. Myokymia was characterized by vermicular fibrillary movements localized to the gastrocnemius muscle and accompanied by plantarflexion and dorsiflexion of the toes. Neurologic examination, nerve conduction velocities, electromyograms, and muscle biopsy findings showed affection of left common peroneal and posterior tibial nerves. The myokymia disappeared during sleep, spinal anesthesia, and treatment with carbamazepine.

Adult↗