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Biomedical subjects

J L Lejonc

Publications and source records attributed to J L Lejonc.

At least 37 records · Page 2Linked to original sources

Suicide attempts in hypo-oestrogenic phases of the menstrual cycle.

The phase of the menstrual cycle in women who had attempted suicide was determined by structured interview. 108 young women were investigated within 24 h of the attempt. Patients were grouped according to menstrual week and whether they used oral contraception (OC) (n = 73) or not (n = 35). In OC non-users suicide attempts were associated with low plasma oestradiol: they tended to happen during the first week of the menstrual cycle (42%) and after the fourth week (12%). Frequency of suicide attempts did not vary significantly during the menstrual cycle in OC users. In OC non-users, low oestradiol production may predispose to depression and attempted suicide.

Adult↗

Allopurinol hypersensitivity syndrome as a cause of hepatic fibrin-ring granulomas.

Hepatic fibrin-ring granulomas were found in a 35-yr-old man who developed fever, myalgias, rash, eosinophilia, and abnormal liver function tests 4 wk after the beginning of allopurinol treatment. All clinical and biochemical abnormalities spontaneously resolved within 6 wk after cessation of therapy. There was no evidence for Q fever or Hodgkin's disease, which are the recognized causes of hepatic fibrin-ring granulomas. It is suggested that allopurinol hypersensitivity might be an additional cause of these peculiar granulomas.

Adult↗

Peripheral neuropathy in patients treated with almitrine dimesylate.

Sensory peripheral neuropathy developed in 5 patients treated with almitrine dimesylate, 60-100 mg/day. Onset was insidious, beginning symmetrically in the legs with stocking sensory loss and loss of ankle-jerks. Cerebrospinal fluid protein levels were slightly increased and there was electrophysiological and histological evidence of distal axonopathy. The interval between the first dose of almitrine dimesylate and onset of symptoms ranged from 2 to 4 months in 4 patients. All patients had noted a recent weight loss of 4-15 kg which may have resulted in release of previously bound drug.

Aged↗

Left innominate vein stenosis as a late complication of central vein catheterization.

A patient was seen for acute exercise-induced left superior limb swelling. Phlebography disclosed left innominate vein stenosis and the lack of subclavian vein thrombosis. Ten months earlier, the patient underwent repeated and prolonged central vein catheterization procedures. No other cause of central vein stenosis was evidenced. Emphasis is placed on the symptomatic presenting event, the very late discovery, and the site of stenosis.

Brachiocephalic Veins↗

[Acute Actinobacillus actinomycetem comitans aortic endocarditis].

A 55 year old man presented an acute massive primary aortic endocarditis, with blood cultures showing the presence of Actinobacillus actinomycetem comitans. The rapidly worsening character of this endocarditis, which required an emergency valve replacement, was the hallmark of this case. The clinical and haemodynamic signs of the often missed massive acute aortic incompetence are recalled.

Actinobacillus Infections↗

Fibromuscular dysplasia of the right subclavian artery.

The case of an uncommon form of arterial fibromuscular dysplasia is reported. The anomaly was located in the right subclavian artery. Claudication of the affected limb was the presenting symptom. Angiography was diagnostic in visualizing typical multifocal stenosis of the proximal portion of the right subclavian artery. Complete surgical correction was performed by establishing a carotido-subclavian by-pass graft.

Adult↗

[Idiopathic peliosis hepatis: case report and review of the literature (author's transl)].

Peliosis hepatis is a very uncommon disease defined by pathological lesions located in the liver and in the spleen characterized by blood filled lakes irregularly disseminated throughout parenchyma, without abnormalities of the hepatic veins or the vena cava system. A new case, regularly followed 3 years after the initial diagnosis is reported. Recent reports of the literature have pointed out etiologic factors, particularly iatrogenic factors. None of the reported factors could be found out in the present case. This emphasizes the need of epidemiological studies of such a rare disease (case-control study in a multicentric basis). Finally a successful diagnosis approach is proposed: transvenous (transjugular) liver biopsy. This procedure prevents hemorrhagic risk which could be a complication of routine transcutaneous liver biopsy in this disease.

Aged↗

[Hepatitis of the secondary syphilis (author's transl)].

A case of syphitic hepatitis is reported. This rare manifestation during the second stage, is characterised by a important cholestasis and a moderated cytolysis. The biologic pattern and the histologic findings allow the difference with viral hepatitis. The manifestation is more frequent in homosexual people. The specific treatment is quickly effective and the short and long-term prognosis is good.

Adult↗