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Biomedical subjects

J L Lamarque

Publications and source records attributed to J L Lamarque.

At least 73 records · Page 4Linked to original sources

The use of iodolipids in hepatosplenic computed tomography.

Iodolipids have been used as a contrast medium for hepatosplenic computed tomography (CT) in 148 patients. In all but two of these cases, the contrast material was injected by the intravenous route. The method appears to be safe due to the marked reduction of dosage in CT compared with conventional radiographic iodolipid hepatography. This decreased dosage is made possible by the improved density and spatial resolution of CT. Pictorial and histographic densitometric analysis of normal and abnormal liver after iodolipid administration yields considerable diagnostic improvement.

Fatty Acids↗

[An experimental study to evaluate mineralization of vertebral bone by computerized tomography (author's transl)].

Computerized tomography ("tomodensitometry") should, in principle, be able to calculate the linear attenuation coefficient of a compact or spongy bone volume. This coefficient is related to the amount of mineralization, enabling the use of the Scanner X to measure the density of the bone. Thirty vertebrae from the vertebral columns of 14 subjects who died after acute infections were examined by C.T. and by standard methods, and then calcinified. The correlation between ashes weight-Houns-field number was positive but only moderate (r = 0.54), and lower than the result obtained (r = 0.84) with standard methods. Errors occur with presently used apparatuses which are related to: polychromatism, too high an energy of the beam, artefacts, and the effects of "partial volume". Futhermore, the mineral concentration by unit of vertebral volume is very low, and large variations must occur for it to be detectable. Finally, considerable errors arise from the intravertebral bone fat. Suggestions are made with the objective of improving the quality of C.T. as a measuring instrument.

Densitometry↗

[Therapeutic angiography in hemoptysis (author's transl)].

Clinical results of therapeutic bronchial artery embolization in 100 patients are presented. The most frequent causes were chronic fibroproductive tuberculosis and bronchiectasis. 85 patients were cured, 10 patients showed recurrent bleeding and in 4 patients bleeding could not be stopped. Complete embolization of all supplying vessels is of great importance to achieve successful results. Caution has to be applied not to risk medullary complications.

Adult↗

[Tomodensitometry in osteoarticular pathology. Preliminary results].

From the investigation of 180 patients, the preliminary results of tomo-densitometric study ("scanning") of the locomotor system are presented. The technique permits investigation in the transverse spatial plane, which is ignored in conventional radiology. We feel this to be a major advantage in osteo-articular disease, especially for the spine (measurement of the diameter of the canal, analysis of the posterior structures), the sacro-iliac joints, hip joints (easy-measurement of the angles of anteversion) and patello-femoral joints. The densitometric measurement is the second advantage. It allows the estimation of the degree of bony calcification of any bone in the body with great precision. The preliminary study already demonstrates the limitations of the technique (exploration of a single transverse plane, edge effect, and necessity for a new anatomy).

Bone Diseases↗

[Hepatic and pancreatic tomometry. Radioanatomy and application to hepatic pathology].

More than 250 hepatic and pancreatic tomometries were carried out on a first generation tomometer. Anatomical and tomometric correspondances carried out on the cadaver led to precise radiological anatomy of the abdomen. Tomometry either alone or carried out after impregnation of the liver parenchyma with an emusion of lipiodol in low dosage permits one to demonstrate hepatic lesions of the order of one centimeter diameter whatever their localisation. Densitometry differentiates not only solid lesions from fluid lesions but permits in certain cases a diagnosis of the nature of the lesion.

Animals↗

[Abdominal tomometry. 1st results in exploration of the liver and pancreas].

Over a two month period, 120 patients were explored using an Acta Scanner tomometer for various hepatic disorders. In parallel, comparison was made of anatomical slices and computed tomography findings in cadavers and isolated livers. This made it possible to recognise normal structures seen at computed tompgraphy and to identify certain hepatic images which might be sources of error. Serial transverse axial sections were used to reconstruct the whole liver in space, thereby making it possible to eliminate certain cases of pseudotumoral hepatomegaly. Systematic densitometry was carried out using hepatic radio-anatomical and pathological studies. This new type of analysis led to a quantified diagnosis in certain diffuse hepatic disorders and a histological approach to tumour lesions. Hepatography using special contrast agents in very low dosage was used in liver computed tomography after animal experiments. This method, free of untoward effects, makes possible the diagnosis of hepatosplenic tumour lesions less than one centimetre in diameter.

Cadaver↗

[Semiology of benign diseases of the breast in mammography (author's transl)].

Mammography is a basic examination which must never be dissociated from the clinical background. A statistical blind study of 330 cases shows that only well definite syndroms are reliable. The presence of absence of a single sign has no value. Difficulties arise in the diagnosis of suspect nodule in a dense dystrophic breast. Hydratation of the connecting tissue is a fundamental concept for analysis of mammographic pictures. The densities change according to hormonal influence, growth of dystrophy and specific signs of fibrillary or hyalin fibrosis. A histological study of serial cuts of the breast shows that the must reliable signs are found in the center of the nodule ande immediately around it. As in the histological study, serial cuts are indispensable in X-ray examination. Tomography improves the examination of dystrophies.

Breast↗

[Abdominal tomometry. Application to study of the liver. Experimental study, initial clinical results and perspectives in the exploration of tumour pathology (author's transl)].

Over a period of two months, 120 patients were studied using an Acta-Scanner tomometer for various hepatic disorders. In parallel, comparative tomometric and pathological studies were carried out in cadavers and isolated livers. These made possible the recognition of normal structures in tomometry and the identification of certain hepatic images which might be potential sources of error. Serial axial transverse sections were used to reconstruct the volume of the liver in space, thus making in possible to eliminate certain forms of pseudo-tumoural hepatomegaly. Systematic densitometric analysis was made by radiological anatomical study and in hepatic pathology. This new type of analysis led to a quantified diagnosis of certain diffuse hepatic diseases and a histological approach to tumour lesions. Hepatography using liposoluble agents in very low dosage was used in hepatic tomometry after animal experimentation. The method, free of untoward effects, makes possible the diagnosis of hepato-splenic tumor lesions less than one centimetre in diameter.

Absorptiometry, Photon↗

[Mammotomography, a new technic of breast examination].

The authors present the first results of a new technique of breast examination: tomo-mammography. This new method allows a complete study of the whole gland without any compression and any modification of histological and anatomical structures, and an analysis of the center of breast lesions in which are rassembled the most reliable radiological signs. These first results enable to hope a large increase of possibilities of diagnosis of breast lesions in the most difficult anatomical and clinical cases.

Breast↗

[Thoraco-abdominal angiotomography. 280 explorations].

Angiotomography invariably imrpves the quality of the images obtained in vascular radiology, with respect to both vascular anatomy and pathology. Its contribution is obviously essential when, for technical reasons, arterial opacification is only mediocre (extended angiocardiopneumography). In the arteriolar study of deep seated or voluminous organs, its eliminates superimpositions, makes tri-dimensional study possible and provides a means of studying fine arterioles, useful in diagnosis and difficult to demonstrate using conventional techniques. Its principle limitations are technological in character. Accepting precise and clearly defined rules in its indications and realisation, appropriate equipment, and a constant effort in the analysis and reading of its results, it is reasonable to hope that angiotomography will quickly add a new dimension to vascular studies.

Abdomen↗

Hepatosplenography by intravenous injection of a new iodized oily emulsion.

Hepatosplenography with intravenously injected iodized lipid emulsion has been performed in 30 cases and the results reported. The side effects were minor and transient, as the elimination is rapid. The uptake in the liver was satisfactory and permitted tomography both of the liver and the spleen. Small neoplasms and splenic nodules in Hodgkin's disease could be detected and located accurately.

Emulsions↗