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Biomedical subjects

J L Konzelman

Publications and source records attributed to J L Konzelman.

At least 19 recordsLinked to original sources
PubMed1997

Current perspectives on dental patients receiving coumarin anticoagulant therapy.

Despite approximately 40 years of experience with oral anticoagulant drugs, controversy still exists about the safety of dental treatment in a patient receiving this therapy. The authors review the topic in depth and offer detailed recommendations for the dental management of patients receiving coumarin anticoagulant therapy.

Anticoagulants↗
PubMed1996

Angina: an update for dentistry.

Advances in medicine have dramatically altered the diagnosis and treatment of angina and the prognosis for patients with this condition. The authors review current medical practices and make recommendations for the dental management of patients.

Angina Pectoris↗
PubMed1992

Iontophoresis of vinblastine into normal skin and for treatment of Kaposi's sarcoma in human immunodeficiency virus-positive patients. The Military Medical Consortium for Applied Retroviral Research.

BACKGROUND: Patients who test positive for human immunodeficiency virus type 1 (HIV-1) and who have disfiguring and/or painful cutaneous lesions of Kaposi's sarcoma (KS) may not be candidates for systemic chemotherapy and/or immunotherapy. Intralesional vinblastine sulfate, as a single-agent chemotherapeutic drug, has been used with some success to treat KS in patients who are HIV-1 positive. However, some patients may not tolerate the pain associated with injection of vinblastine. Transcutaneous iontophoresis of vinblastine was evaluated for therapy of KS in HIV-1-infected patients. Prior to therapy of patients, we iontophoresed vinblastine into the normal skin of volunteers who were not infected with HIV-1 to document the clinical and histologic features that occurred. OBSERVATIONS: Iontophoresis produced a localized erythematous papular eruption in non-HIV-infected volunteers but not in HIV-1-infected patients. Histologic changes in the biopsy specimens taken from non-HIV-infected volunteers consisted primarily of scattered necrotic keratinocytes and a mild to moderate superficial lymphohistiocytic infiltrate. Thirty-one lesions of KS were treated with partial to complete clearing and symptomatic improvement. CONCLUSION: Clinical and histologic features of iontophoresed normal skin suggest an immunologic mechanism of action. Iontophoresis of vinblastine for KS is well tolerated and results in symptomatic improvement as well as varying degrees of clearing of the lesions.

Adult↗
PubMed1991

HIV and periodontal health. A study of military personnel with HIV.

In 230 military personnel who were seropositive for the human immunodeficiency virus, the prevalence of viral and fungal infections in the mouth was clearly related to the degree of immune dysfunction as measured by T4-lymphocyte counts. The relation between periodontal health and T4 counts was less clear. Tobacco use was related to the increased occurrence of both mucosal lesions and periodontal diseases.

Adolescent↗
PubMed1991

Oral manifestations of human immunodeficiency virus infection.

Oral candidiasis, herpetic lesions, oral mucosal warts, human immunodeficiency virus-associated gingivitis and periodontitis, Kaposi's sarcoma, hairy leukoplakia, and non-Hodgkin's lymphoma are oral manifestations of infection by the human immunodeficiency virus. This paper will explain how to identify these lesions, their significance, and recommended treatments.

Candidiasis, Oral↗
PubMed1987

Comparison of meclofenamate sodium with buffered aspirin and placebo for the relief of postoperative dental pain.

The analgesic effect of meclofenamate sodium at two dose levels (100 mg and 200 mg) was compared with the effects of buffered aspirin (600 mg) and placebo in a double-blind, randomized study of 105 dental outpatients with acute pain following third-molar extraction. Meclofenamate sodium at either dose level was significantly superior to both buffered aspirin and placebo, resulting in significantly greater relief of pain. All four treatments were well tolerated, and side effects were minimal. Meclofenamate sodium is a safe, highly effective analgesic for the relief of acute pain.

Adolescent↗
PubMed1979

Transposition of teeth.

Transposition is a rare dental anomaly. Two cases of transposition of canines have been presented, the causes are discussed, and modes of treatment are suggested.

Adult↗
PubMed1979

Intraoral blue nevus--a review.

The clinical characteristics and appearance of the intraoral blue nevus are reviewed herein. The histogenesis, histologic appearance, differential diagnosis, and treatment of this uncommon oral lesion are also discussed.

Humans↗