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Biomedical subjects

J L Jackson

Publications and source records attributed to J L Jackson.

101 records · Page 6Linked to original sources
PubMed1966

Effect of actinomycin D on immune antibody, normal antibody, and complement.

Muschel, Louis H. (University of Minnesota, Minneapolis), Jean L. Jackson, and Karen Schmoker. Effect of actinomycin D on immune antibody, normal antibody, and complement. J. Bacteriol. 91:270-272. 1966.-The effect of actinomycin D on the immune response, when the antibiotic was administered to rabbits simultaneously with antigen, and its effect on naturally occurring levels of antibody and complement were determined. Those amounts of the antibiotic that effected a significant suppression of the immune response against deliberately injected antigens did not cause a decline in levels of naturally occurring antibody. Complement titers were also refractory to the antibiotic.

Animals↗
PubMedDate not supplied

Effects of physician awareness of symptom-related expectations and mental disorders. A controlled trial.

OBJECTIVE: To study whether physician awareness of symptom-related expectations and mental disorders reduces unmet expectations or improves patient satisfaction. DESIGN: Prospective, before-after trial, with control (n = 250) and intervention (n = 250) groups. Outcomes were assessed immediately after the index office visit, at 2 weeks, and at 3 months. SETTING: Ambulatory walk-in clinic. PARTICIPANTS: Five hundred adults with physical complaints. Exclusion criteria included upper respiratory tract infection and dementia. Follow-up was accomplished in 100% immediately after the visit, 92.6% at 2 weeks, and 82.6% at 3 months. INTERVENTIONS: Two-hour physician workshop followed by information provided before each visit on patient expectations, illness worry, and Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) disorders. MEASUREMENTS: Symptom-related expectations, satisfaction with care, symptom improvement, functional status, physician-perceived difficulty of the encounter, visit costs, and use of health care services. RESULTS: Serious illness worry (64%), 1 or more specific expectations (98%), or a DSM-IV disorder (29%) were commonly present in study patients. Intervention patients were less likely to report unmet expectations (odds ratio, 0.52; 95% confidence interval [CI], 0.43-0.97) immediately after the visit and at 2 weeks, less likely to be perceived as difficult by their physician (odds ratio, 0.49; 95% CI, 0.24-0.98), and more likely to be fully satisfied at 2 weeks (odds ratio, 1.63; 95% CI, 1.14-2.00). By 3 months, groups were similar in terms of satisfaction and residual expectations. Symptom improvement occurred in most patients by 2 weeks (70.5%) and 3 months (81.2%), regardless of study group. There was also no difference in patients' serious illness worry during the follow-up. The intervention did not increase visit costs or use of health care services. CONCLUSION: Identifying symptom-related expectations and mental disorders in patients presenting with physical complaints may improve satisfaction with care at 2-week follow-up and physician-perceived difficulty of the encounter.

Ambulatory Care↗
PubMedDate not supplied

Clinical predictors of mental disorders among medical outpatients. Validation of the "S4" model.

The authors previously reported four clinical cues that predicted a subgroup of ambulatory patients likely to have depressive and anxiety disorders. The authors' purpose in this study was to validate this model in another cohort of 185 consecutive adult referrals to a rheumatology clinic. The authors found 4 variables important in predicting mental disorders: recent stress (odds ratio [OR]: 3.3, 95% confidence interval [CI]: 1.5-7.1); > 5 somatic symptoms (OR: 4.5, 95% CI: 1.1-9.5); only fair or poor health status (OR: 3.4, 95% CI: 1.6-7.4); and symptom severity (OR: 1.6, 95% CI: 0.8-3.6). There was a stepwise increase in the likelihood of a mental disorder with an increasing number of predictors. The authors conclude that these clinical cues may allow clinicians to select patients in which formal screening for mental disorders would be particularly fruitful.

Adolescent↗
PubMedDate not supplied

Predicting the criminal antecedents of a stranger rapist from his offence behaviour.

Approximately 85% of stranger rapists have criminal records, which usually contain a mixture of crime types. This study was designed to ascertain if inferences about such records could be made from aspects of offence behaviour, as described by the rape victims, focusing on both non-sexual behaviours and traits more obviously associated with previous criminality. The statistical technique used was logistic regression. The results demonstrated that it was very possible to obtain indications of a rapist's criminal antecedents from his offence behaviour. The three most promising models were those that predicted whether or not the offender had convictions for burglary, whether or not he had convictions for violent offences, and whether the offence was an apparent 'one-off' occurrence rather than the work of an experienced rapist.

Behavior↗
PubMedDate not supplied

Plantaris tendon reconstruction of the lateral ankle ligaments.

Numerous procedures have evolved to operatively stabilize the ankle suffering from chronic inversion instability. The use of the plantaris tendon to anatomically reconstruct the lateral collateral ankle ligaments is among those that avoid the complication of restriction of subtalar joint range of motion. The authors present a modified technique of reconstructing the calcaneofibular and anterior talofibular ligaments using a plantaris tendon that maintains its insertion. A retrospective study of eight patients that elected the procedure for chronic ankle instability was conducted. The average follow-up was 12.7 months. Significant improvement in functional score (p less than 0.01) and talar tilt (p less than 0.05) was noted following the procedure. No restriction of subtalar joint motion was observed in any patient after the procedure. The advantages and disadvantages of the procedure are discussed. The authors conclude that the procedure appears to be a desirable alternative in achieving ankle stability while maintaining normal hindfoot function.

Adolescent↗