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Biomedical subjects

J L Hollander

Publications and source records attributed to J L Hollander.

At least 19 recordsLinked to original sources
PubMed1988

Joint problems in the elderly. How to help patients cope.

Osteoarthritis (degenerative joint disease) is almost always present to some degree in persons over 60 years of age. It may also occur earlier in life because of genetic predisposition, hormonal dysfunction, or previous trauma. Concomitant forms of arthritis must be differentiated from osteoarthritis and properly treated. Management of osteoarthritis starts with patient education on moderating activity and avoiding local joint stresses. Caution in use of nonsteroidal antiinflammatory drugs is essential. Local injection of corticosteroids in small amounts into particularly symptomatic joints may yield long-term or repeatable local relief. When an adequate trial of conservative measures fails to preserve or permit reasonably moderate function of a joint, surgical correction must be considered.

Adrenal Cortex Hormones↗
PubMed1985

Synovial fluid crystals in osteoarthritis.

Apatite crystals, calcium pyrophosphate dihydrate crystals, or both were observed in knee joint effusions from 60% of 100 consecutive osteoarthritis (OA) patients. Crystals were mor common in patients with more severe OA and in joints that had received previous intraarticular steroid injections. Whether the latter was predominantly related to an effect of the steroid or to the fact that steroids were used in more severe cases was not clear. Crystals existed in many effusions without elevated synovial fluid leukocyte counts. A subgroup of 7 patients had both types of crystals, more crystal phagocytosis, and more severe OA.

Aged↗
PubMed1980

Osteoarthritis: perspectives on treatment.

Osteoarthritis is an almost universal complication of aging, analogous to arteriosclerosis. Most important in management is education of the patient, which fosters intelligent cooperation. Reduction of stress on affected joints is essential. Relief of symptoms can be achieved locally by steroid injection or systemically by administration of nonsteroidal antiinflammatory drugs, but complete obliteration of symptoms may cause harm by encouraging continued abuse of the damaged joint. When all else fails and the osteoarthritic joint is persistently painful even on limited use and/or its function has been greatly restricted, then replacement surgery should be considered.

Anti-Inflammatory Agents↗
PubMed1978

Painful joints. Clues to early diagnosis.

Many cases of joint pain may be diagnosed from clinical findings alone. A careful history and physical examination are essential. Of all diagnostic laboratory tests for joint disease, none is completely specific. Results of latex fixation tests, antinuclear antibody (ANA) tests, and uric acid tests are all strongly suggestive when positive but do not rule out disease when negative. The most valuable laboratory procedure is examination of the synovial fluid. X-ray examination seldom is helpful in differentiation of early joint disease but may be very helpful in later stages.

Antibodies, Antinuclear↗
PubMed1975

Familial chondrocalcinosis in the Chiloe Islands, Chile.

Studies about chondrocalcinosis in the Chiloe Islands (Chile) showed the high frequency of the disease there and how most of it is aggregated in a few highly involved families. Pedigrees and the high degree of consanguinity among parents of index cases pointed to a recessive inheritance. The presence of common Caucasian anthropological features of genetic value in the patients and the lack of Indian mixture in three of the involved families, documented back to 1600, suggest a Caucasian origin of the mutation. Biochemical studies of the patients' synovial fluid showed a significant rise in pyrophosphate concentration. Calcium, phosphorus, and alkaline phosphatase concentrations were not different from a control group.

Adult↗
PubMed1970

Arthritis.

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Analgesics↗