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Biomedical subjects

J L Hicks

Publications and source records attributed to J L Hicks.

46 records · Page 3Linked to original sources
PubMed1975

Correlation of acute with chronic hypoxic pulmonary hypertension in cattle.

We investigated acute and chronic hypoxic pulmonary pressor responses in two groups of calves, one bred to be susceptible, the other resistant to high-altitude pulmonary hypertension. Twelve 5-mo-old susceptible calves residing at 1,524 m increased their mean pulmonary arterial pressure from 26 +/- 2 (SE) to 55 +/- 4 mmHg during 2 h at a simulated altitude of 4,572 m. In 10 resistant calves pressure increased from 22 +/- 1 to 37 +/- 2 mmHg. Five calves were selected from each group for further study. When 9 mo old, the 5 susceptible calves again showed a greater pressor response to acute hypoxia (27 +/- 1 to 55 +/- 4 mmHg) than did 5 resistant calves (23 +/- 1 to 41 +/- 3 mmHg). When 12 mo old, the 5 susceptible calves also developed a greater increase in pulmonary arterial pressure (21 +/- 2 to 9 +/- 4 mmHg) during 18 days at 4,572 m than did the 5 resistant calves (21 +/- 1 to 64 +/- 4 mmHg). Acute and chronic hypoxic pulmonary pressor responses were highly correlated (r = 0.91; P less than 0.001) indicating that they were probably produced through a common mechanism.

Age Factors↗
PubMedDate not supplied

Microleakage of five temporary endodontic restorative materials.

This study evaluated the ability of five interim endodontic restorative materials to resist microleakage. Sixty extracted human molars were prepared for initial endodontic therapy via occlusal access preparations. After removal of the pulpal tissue, a cotton pellet was placed in the pulp chamber. The access preparations were sealed with one of the following materials or combinations: TERM, Cavit, IRM, Ketac-Silver, or a IRM-Cavit "sandwich" restoration. The specimens were thermocycled for 24 hours (800 cycles), immersed in methylene blue dye for 4 hours, sectioned, and evaluated under a microscope for microleakage. TERM, Cavit, and the IRM-Cavit "sandwich" had virtually no microleakage, while Ketac-Silver and IRM exhibited gross microleakage.

Calcium Sulfate↗
PubMedDate not supplied

The relationship of oral Candida tropicalis infection to systemic candidiasis in a patient with leukemia.

Oropharyngeal candidiasis is an extremely common complication in patients receiving chemotherapy for leukemia. Candida tropicalis appears to be the major infectious agent when these patients develop candidemia. In this article, a case of C tropicalis fungemia with oropharyngeal manifestations is presented. The relationship of oropharyngeal candidiasis to oral candidal infection is discussed.

Adult↗
PubMedDate not supplied

In vivo metabolism of isoxicam in rats, dogs, and monkeys.

Isoxicam is a long half-life nonsteroidal anti-inflammatory agent which undergoes extensive metabolism prior to elimination in animals and man. The major route of isoxicam transformation is hydroxylation of the methylisoxazole functionality to form hydroxymethylisoxicam, and cleavage of its benzothiazine moiety to give an oxoacetic acid metabolite. The metabolic pathway for scission of the benzothiazine moiety to the oxoacetic acid metabolite and to other potential metabolites is not known. To gain additional information on the metabolic fate of isoxicam, 14C-isoxicam labeled on the N-methyl group was administered to rats, dogs, and monkeys with urine and feces collected for metabolic profiling and identification. Identified as new metabolites of isoxicam were an open-ring sulfonamide, N-methylsaccharin, and saccharin. The formation of these metabolites suggests that isoxicam undergoes direct oxidative scission of its benzothiazine ring at carbon atom 3 to generate the observed open-ring sulfonamide, N-methylsaccharin, and oxoacetic acid metabolites.

Animals↗
PubMedDate not supplied

Bilateral coronoid hyperplasia: an important cause of restricted mandibular motion.

The diagnosis of coronoid hyperplasia relies on clinical history as well as physical findings. A history of slowly progressive limitation of motion should heighten one's index of suspicion that the limitation may not necessarily be due to a simple muscular disorder or a disorder involving the temporomandibular joint per se. Absence of a history of internal derangement is an important consideration. Simple screening films should be employed prior to subjecting the patient to more detailed studies. A panogram and Waters' projection of the mid-face are quite diagnostic. Utilization of tomography, arthrography, and magnetic resonance imaging should be considered only after appropriate screening films have been reviewed.

Adult↗