Search PubMed⌕ Search

Biomedical subjects

J L Harkness

Publications and source records attributed to J L Harkness.

27 records · Page 2Linked to original sources
PubMed1981

Antibacterial activity of five cephalosporins.

The in vitro susceptibilities of 7 commonly isolated species of bacteria to cephalothin, cefoxitin, and 3 new cephalosporins--cephamandole, cefuroxime, and cefoperazone--were studied using an agar dilution method. Cephalothin and cephamandole were the most active agents against staphylococci. Against members of the Enterobacteriaceae all the newer agents were more active than cephalothin; however, important individual differences emerged. Only cefoperazone had significant activity against Pseudomonas aeruginosa.

Bacteria↗
PubMed1980

Disseminated fusarium infection.

A case of disseminated Fusarium sp. infection in a bone-marrow transplant patient is described. The most likely source of the organism was food, and the importance of a specially prepared diet in immunosuppressed individuals is emphasized.

Adult↗
PubMed1980

Endocarditis due to an atypical mycobacterium following porcine heart valve replacement.

Following aortic valve replacement with a porcine xenograph, a patient developed endocarditis complicated by a fistula between aorta and right ventricle. The xenograph was replaced by a mechanical valve and the fisutla oversewn. No organisms were cultured but acid-fast bacilli were seen in the aortic wall and excised valve tissue. It is likely that these were contaminants of the porcine prosthesis.

Aortic Valve↗
PubMed1978

Clinical usefulness of susceptibility testing of anaerobes.

We have studied the clinical usefulness of antibiotic susceptibility testing of fresh clinical isolates of anaerobes (primarily from blood cultures). Analysis of 65 patients showed that susceptibility reports were used in only 13 instances (20%), representing mainly orothopedic and CNS infections. Of the 47 patients whose susceptibilities were not used, 20 received therapy (appropriate in each case) based on the culture report, and 27 were treated empirically. Only six patients in the empirically treated group received inappropriate treatment, but four of those six died, and patients in this group as a whole had a worse outcome than did patients in the other groups. However, these empirically treated patients also had a somewhat worse prognosis. We suggest that susceptibility testing of anaerobes be reserved for bacteremic patients and for managing severe, chronic anaerobic infections, such as septic arthritis, osteomyelitis, and brain abscesses.

Anti-Bacterial Agents↗
PubMed1975

Effects of atmosphere of incubation and of routine subcultures on detection of bacteremia in vacuum blood culture bottles.

Studies comparing isolation rates of bacteria and yeasts from vented and unvented vacuum blood culture bottles containing soybean-casein digest broth showed significantly more frequent and more rapid recovery of Candida and Pseudomonas from the vented bottle and no other statistically significant differences between the two. Subculture of bottles on the day of their collection was shown to accelerate recovery of 48% of positive cultures by day 1. A second subculture of known positive cultures yielded additional organisms in 1.5% of cultures.

Air↗