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Biomedical subjects

J L Hall

Publications and source records attributed to J L Hall.

At least 145 records · Page 8Linked to original sources
PubMed1977

African hamster lymphocytes as a model for immunologic studies.

The mitogenic response of splenic lymphocytes from Mystromys albicaudatus was studied to evaluate the potential of this animal as a model for immunologic research. In response to phytochemagglutinin and concanavalin A, splenic cells from Mystromys, unlike those from mouse strains, incorporate [3H] thymidine optimally in microculture at 10(5) to 2 X 10(5) cells per microculture. Maximum magnitude of incorporation in response to the same doses of mitogen used in mouse splenic lymphocyte microculture is greater than 10(5) cpm. Moreover, this high incorporation at low cell concentration has been observed in cultures from animals ranging from six to 24 months of age. Splenic cells from Mystromys give little or no incorporation with either LPS or PPD in doses mitogenic to mouse lymphocytes. These features of mitogenic response in Mystromys lymphocyte cultures suggest several useful applications to studies of mechanisms of mitogenesis.

Animals↗
PubMed1976

Cystourethrography procedures in children. Evaluation of benefits versus dose.

Cystourethrography was used by the referring physician in 53 children with urinary tract disease. The benefits of this technique were evaluated using Bayesian methods. Prior and subsequent odds of the accuracy of the clinical diagnosis being affected by the radiological procedure were estimated. Marked benefits were found in 12 cases, which were used as the basis for the most conservative estimate of benefits. The genetic benefit-risk ratio is 140 for boys and 8.3 for girls. The somatic benefit-risk ratio is 10,000 for boys and 4,200 for girls.

Child↗
PubMed1976

Evaluation of the sensitivity of commercially available digoxin radioimmunoassay kits.

We have evaluated the technical minimum detection limits of 12 different commercially available kits and the practical minimum detection limits of 11 kits used for the determination of the serum digoxin level by radioimmunoassay. The poor technical ability of many of the kits to distinguish between digoxin levels of 0.1 ng/ml intervals between 0 and 0.5 ng/ml and, additionally, the detection of a digoxin level up to 0.3 ng/ml with some of the kits in glycoside-free sera impose a practical working minimum detection limit of 0.5 ng/ml for the majority of these kits. We, therefore, recommend caution with interpreting or evaluating serum digoxin levels below 0.5 ng/ml.

Digoxin↗