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Biomedical subjects

J L Griffith

Publications and source records attributed to J L Griffith.

At least 73 records · Page 4Linked to original sources
PubMed1981

A comparative study of selective stimulation of raphe nuclei in the cat in inhibiting dorsal horn neuron responses to noxious stimulation.

Consistent inhibition of cord nociceptive neurons was obtained at low levels of stimulation (5 V or 50-100 micro A) within raphe magnus. Less consistently and with higher stimulus intensities, inhibition was observed on stimulating raphe pallidus. Still less frequently, and generally only with stimulation in the 20 V or 500 micro A range, inhibition was observed in raphe dorsalis, raphe obscurus and centralis superior. No inhibition could be obtained by stimulation in linearis intermedias or linearis rostralis. Nearly all midline sites where inhibition of cord nociceptive neurons was observed were those within or in immediate proximity to raphe nuclei.

Animals↗
PubMed1980

A twenty-year experience with surgical management of carcinoma of the esophagus and gastric cardia.

Twenty years of experience with operative treatment of carcinoma of the esophagus and cardia are reviewed. Of the 513 patients with biopsy-proved malignancy reviewed, 211 (41%) underwent gastroesophagectomy. The hospital mortality rate for the patients operated upon was 12%. The 3 year survival rate was 26% and the 5 year survival rate was 15% for the entire surgical series. Squamous cell carcinomas of the lower third were the most favorable subgroup (25% 5 year survival) and lower third adenocarcinomas the least favorable (8% 5 year survival). Our procedure of choice is a one-stage resection with stomach used to restore continuity. Operative details and perioperative management are reviewed. The single-layer wire technique of anastomosis seems to give acceptably low rates of anastomotic leak (4.2%) and stricture (2.3%). Preoperative radiation was not used in this series.

Adenocarcinoma↗