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Biomedical subjects

J L Gilbert

Publications and source records attributed to J L Gilbert.

62 records · Page 4Linked to original sources
PubMed1987

[Endomorphines in schizophrenia].

The biological enigma of schizophrenia has led, on the basis of thin evidence, to widen the field of clinical research to a study of endomorphines in this disease. Too many different methods of measuring the levels of opiate peptides in the CSF have been used so that it is not possible to analyse the results statistically. Clinical trials of agonists and antagonists to the opiate receptors have once again emphasised the biochemical heterogeneity of schizophrenics but have not allowed any confirmation that the endorphinical system plays any part in the genesis or symptomatology of schizophrenia. The presence of sub-groups who respond positively to experimental treatment can lead to the hope, despite the uncertainties of their mode of pharmacological action, to the next advance in the routine treatment of schizophrenia.

Clinical Trials as Topic↗
PubMedDate not supplied

Correlation of coagulopathy and pulmonary insufficiency with blood transfusion in spinal fusions.

In a review of 210 spinal fusions, the platelet count and the arterial-alveolar oxygen tension ratio both decreased as the blood transfused increased, but were not correlated with positive fluid balance. In procedures that might require more than 70-80 ml/kg of blood, such as myelodysplastic, paralytic, and congenital spinal surgery, the coagulation system and arterial gases should be monitored frequently intraoperatively and postoperatively.

Adult↗
PubMedDate not supplied

Profit pools: a fresh look at strategy.

In charting strategy, many managers focus on revenue growth, assuming that profits will follow. But that approach is dangerous: today's deep revenue pool may become tomorrow's dry hole. To create strategies that result in profitable growth, managers need to look beyond revenues to see the shape of their industry's profit pool. The authors define an industry's profit pool as the total profits earned at all points along the industry's value chain. Although the concept is simple, the structure of a profit pool is usually quite complex. The pool will be deeper in some segments of the value chain than in others, and depths will vary within an individual segment as well. Segment profitability may, for example, vary widely by customer group, product category, geographic market, and distribution channel. Moreover, the pattern of profit concentration in an industry will often be very different from the pattern of revenue concentration. The authors describe how successful companies have gained competitive advantage by developing sophisticated profit-pool strategies. They explain how U-Haul identified new sources of profit in the consumer-truck-rental industry; how Merck reached beyond its traditional value-chain role to protect its profits in the pharmaceuticals industry; how Dell rebounded from a misguided channel decision by refocusing on its traditional source of profit; and how Anheuser-Busch made a series of astute product, pricing, and operating decisions to dominate the beer industry's profit pool. The companies with the best understanding of their industry's profit pool, the authors argue, will be in the best position to thrive over the long term.

Capital Financing↗
PubMedDate not supplied

How to map your industry's profit pool.

Many managers chart strategy without a full understanding of the sources and distribution of profits in their industry. Sometimes they focus their sights on revenues instead of profits, mistakenly assuming that revenue growth will eventually translate into profit growth. In other cases, they simply lack the data or the analytical tools required to isolate and measure variations in profitability. In this Manager's Tool Kit, the authors present a way to think clearly about where the money's being made in any industry. They describe a framework for analyzing how profits are distributed among the activities that form an industry's value chain. Such an analysis can provide a company's managers with a rich understanding of their industry's profit structure--what the authors call its profit pool--enabling them to identify which activities are generating disproportionately large or small shares of profits. Even more important, a profit-pool map opens a window onto the underlying structure of the industry, helping managers see the various forces that are determining the distribution of profits. As such, a profit-pool map provides a solid basis for strategic thinking. Mapping a profit pool involves four steps: defining the boundaries of the pool, estimating the pool's overall size, estimating the size of each value-chain activity in the pool, and checking and reconciling the calculations. The authors briefly describe each step and then apply the process by providing a detailed example of a hypothetical retail bank. They conclude by looking at ways of organizing the data in chart form as a first step toward plotting a profit-pool strategy.

Capital Financing↗
PubMedDate not supplied

The work evaluator.

Explore the source record for details and available documents.

Adult↗
PubMedDate not supplied

Mechanical properties of titanium connectors.

The tensile mechanical properties of welded titanium joints were studied, and intact titanium was used as controls. Welded joints were fabricated with either a stereographic laser-welding technique or a gas tungsten arc welding technique. The effect of heat treatment following a simulated porcelain application was also investigated. Heat-treated laser welds had significantly lower ultimate tensile strengths. Heat treatment had no effect on the modulus of elasticity or elongation, but generally significantly decreased the yield strength of the titanium specimens. The gas tungsten are welding specimens had significantly higher yield strengths and elastic moduli than the other two groups. The elongation of the control specimens was significantly greater than the elongation of the gas tungsten arc welding specimens, which was in turn significantly higher than that of the laser-welded specimens.

Analysis of Variance↗