Effects of retinal degeneration and brain size upon spatial reversal learning in mice.
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Biomedical subjects
Publications and source records attributed to J L Fuller.
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Strain SJL/J mice exposed to loud bell-ringing (primed) with one ear blocked do not convulse, but are susceptible to audiogenic seizures 48 hours later when stimulated only through the ear open at priming. Mice stimulated through the ear blocked at priming do not convulse, but are convulsible when retested on the opposite ear. The site of sensitization appears to be either in the ear or in those portions of the auditory system receiving input only from one side.
The incidence of initial audiogenic seizures in mice from crosses between a susceptible and a resistant inbred strain is attributable to the effects of a single pair of alleles. The locus responsible for this behavioral variation is located in Linkage Group VIII of the mouse. Sensitization-dependent convulsions are influenced in whole or in part by alleles at an independent locus.
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Our experiments on the effects of experimental deprivation upon later behavior of dogs have dealt with four major areas. The programming of life histories has involved the scheduling of breaks in isolation and the introduction of specific stimuli to isolation cages. Biweekly breaks, of less than 10 minutes each, largely counteract the effects of isolation. An opportunity for the animal to look out of the isolation cage has some counteracting effect, but the presence of playthings or rearing with a companion does not.
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